Ubiquitination of the human immunodeficiency virus type 1 Env glycoprotein

被引：17

作者：

Bültmann, A ^{[1
]}

Eberle, J ^{[1
]}

Haas, J ^{[1
]}

机构：

[1] LMU, Genzentrum, Max Von Pettenkofer Inst, D-81377 Munich, Germany

来源：

JOURNAL OF VIROLOGY | 2000年 / 74卷 / 11期

关键词：

D O I：

10.1128/JVI.74.11.5373-5376.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Expression of the human immunodeficiency virus type 1 (HIV-1) Env glycoprotein is stringently regulated in infected cells, The majority of the glycoprotein does not reach the cell surface but rather is retained in the endoplasmic reticulum or a cis-Golgi compartment and subsequently degraded. We here report that Env of various HIV-1 isolates is ubiquitinated at the extracellular domain of gp41 and that Env expression could be increased by lactacystin, a specific proteasome inhibitor, suggesting that the ubiquitin/proteasome system is involved in control of expression and degradation.

引用

页码：5373 / 5376

页数：4

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