BMPRII is a direct target of miR-21

被引：57

作者：

Qin, Wenming ^{[1
]}

Zhao, Botao ^{[1
]}

Shi, Yi ^{[1
]}

Yao, Chengguo ^{[1
]}

Jin, Li ^{[2
]}

Jin, Youxin ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Mol Biol, Shanghai 200031, Peoples R China

[2] St Lukes Hosp, Shanghai 200050, Peoples R China

来源：

ACTA BIOCHIMICA ET BIOPHYSICA SINICA | 2009年 / 41卷 / 07期

关键词：

microRNA; miR-21; BMPRII; target; prostate cancer; BONE MORPHOGENETIC PROTEINS; TUMOR-SUPPRESSOR GENE; PROSTATE-CANCER; MICRORNAS; EXPRESSION; CELLS; DIFFERENTIATION; HYPERTENSION; MECHANISMS; MUTATION;

D O I：

10.1093/abbs/gmp049

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

MicroRNAs (miRNAs) are a type of small non-coding RNAs that regulate cognate mRNA expressions at the post-transcriptional stage. Although several miRNAs are known to be involved in various biological processes, including developmental timing, patterning, embryogenesis, differentiation and organogenesis, growth control, and apoptosis, many target genes and the functions of most miRNAs are still unclear. Since there is only a partial complementarity between miRNAs and their targets in animal cells, it is difficult to identify the specific target genes for a given miRNA and elucidate its function. In this study, we confirmed that bone morphogenetic protein receptor II (BMPRII) is a direct target of miR-21, and also showed that the protein level of BMPRII correlates inversely with the amount of miR-21 in PC3 and Lncap cells. These findings suggest that miR-21 may have a potential role in regulating the malignancy and metastatic abilities of prostate cancer cells and in self-renewal of stem cells by regulating the expression of BMPRII.

引用

页码：618 / 623

页数：6

共 30 条

[1]

Primary pulmonary hypertension after amfepramone (diethylpropion) with BMPR2 mutation [J].