An Integrated Microreactor System for Self-Optimization of a Heck Reaction: From Micro- to Mesoscale Flow Systems

被引：187

作者：

McMullen, Jonathan P. ^{[2
]}

Stone, Matthew T. ^{[1
]}

Buchwald, Stephen L. ^{[1
]}

Jensen, Klavs F. ^{[2
]}

机构：

[1] MIT, Dept Chem, Novartis MIT Ctr Continuous Mfg, Cambridge, MA 02139 USA

[2] MIT, Dept Chem Engn, Novartis MIT Ctr Continuous Mfg, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 39期

关键词：

arenes; C-C coupling; microreactors; palladium; synthetic methods; ORGANIC-SYNTHESIS; LIQUID; CATALYSIS;

D O I：

10.1002/anie.201002590

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Set it and forget it: The combination of feedback control and continuous-flow operations in microreactors (see picture) enables online and fully automated reaction optimization. A Heck reaction demonstrates the potential for rapid multivariable reaction optimization while requiring a minimal amount of material. Optimal conditions are quickly scaled-up by a factor of 50. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7076 / 7080

页数：5

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