Behavioral effects of neuropeptide E-I (NEI) in the female rat:: Interactions with α-MSH, MCH and dopamine

被引：38

作者：

Gonzalez, MI

Baker, BI

Hole, DR

Wilson, CA

机构：

[1] St George Hosp, Sch Med, Dept Obstet & Gynaecol, London SW17 0RE, England

[2] Univ Bath, Sch Biol & Biochem, Bath BA2 7AY, Avon, England

来源：

PEPTIDES | 1998年 / 19卷 / 06期

基金：

英国惠康基金;

关键词：

neuropeptide E-I (NEI); melanin concentrating hormone (MCH); alpha-melanocyte stimulating hormone (alpha-MSH); ventromedial nucleus (VMN); medial preoptic area (MPOA); exploration; anxiety; antagonistic behavior; sexual behaviour; serotonin (5-HT);

D O I：

10.1016/S0196-9781(98)00045-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The behavioral and neurochemical effects of NEI, and its interaction with a-MSH or MCH were investigated in the ventromedial nucleus (VMN) and medial preoptic area (MPOA) in female rats (bilateral administration, 100 ng in 0.5 mu l/side). NEI in the VMN (but not in the MPOA) stimulated exploratory behavior, increased anxiety and reduced dopamine and DOPAC release. The behavioral effects were antagonized by alpha-MSH. NEI stimulated female sexual receptivity in the MPOA. In the VMN, NEI did not have any effect on sexual activity, but partially antagonized the stimulatory effect of MCH. These results show that NEI in the hypothalamus participates in the regulation of behavior, possibly through dopaminergic mediation. (C) 1998 Elsevier Science Inc.

引用

页码：1007 / 1016

页数：10

共 32 条

[1] INTERMALE SOCIAL AGGRESSION - SUPPRESSION BY MEDIAL PREOPTIC AREA LESIONS [J].