The next generation of phosphodiesterase inhibitors: Structural clues to ligand and substrate selectivity of phosphodiesterases

被引：111

作者：

Manallack, DT

Hughes, RA

Thompson, PE

机构：

[1] Monash Univ, Victorian Coll Pharm, Parkville, Vic 3052, Australia

[2] Univ Melbourne, Dept Pharmacol, Melbourne, Vic 3010, Australia

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2005年 / 48卷 / 10期

关键词：

D O I：

10.1021/jm040217u

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：3449 / 3462

页数：14

共 67 条

[1] Potential role for P-glycoprotein in the nonproportional pharmacokinetics of UK-343,664 in man [J].

Abel, S ;

Beaumont, KC ;

Crespi, CL ;

Eve, MD ;

Fox, L ;

Hyland, R ;

Jones, BC ;

Muirhead, GJ ;

Smith, DA ;

Venn, RF ;

Walker, DK .

XENOBIOTICA, 2001, 31 (8-9) :665-676

[2] 8-aryl xanthines potent inhibitors of phosphodiesterase 5 [J].

Arnold, R ;

Beer, D ;

Bhalay, G ;

Baettig, U ;

Collingwood, SP ;

Craig, S ;

Devereux, N ;

Dunstan, A ;

Glen, A ;

Gomez, S ;

Haberthuer, S ;

Howe, T ;

Jelfs, S ;

Moser, H ;

Naef, R ;

Nicklin, P ;

Sandham, D ;

Stringer, R ;

Turner, K ;

Watson, S ;

Zurini, M .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (18) :2587-2590

[3] Synthesis and structure-activity relationships of guan analogues as phosphodiesterase 7 (PDE7) inhibitors [J].

Barnes, MJ ;

Cooper, N ;

Davenport, RJ ;

Dyke, HJ ;

Galleway, FP ;

Galvin, FCA ;

Gowers, L ;

Haughan, AF ;

Lowe, C ;

Meissner, JWG ;

Montana, JG ;

Morgan, T ;

Picken, CL ;

Watson, RJ .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (08) :1081-1083

[4]

Barnette MS, 1998, J PHARMACOL EXP THER, V284, P420

[5] Cyclic nucleotide research - still expanding after half a century [J].

Beavo, JA ;

Brunton, LL .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (09) :710-718

[6] High-throughput X-ray crystallography for drug discovery [J].

Blundell, TL ;

Patel, S .

CURRENT OPINION IN PHARMACOLOGY, 2004, 4 (05) :490-496

[7] Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performance [J].

Boess, FG ;

Hendrix, M ;

van der Staay, FJ ;

Erb, C ;

Schreiber, R ;

van Staveren, W ;

de Vente, J ;

Prickaerts, J ;

Blokland, A ;

Koenig, G .

NEUROPHARMACOLOGY, 2004, 47 (07) :1081-1092

[8] A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design [J].

Card, GL ;

Blasdel, L ;

England, BP ;

Zhang, C ;

Suzuki, Y ;

Gillette, S ;

Fong, D ;

Ibrahim, PN ;

Artis, DR ;

Bollag, G ;

Milburn, MV ;

Kim, SH ;

Schlessinger, J ;

Zhang, KYJ .

NATURE BIOTECHNOLOGY, 2005, 23 (02) :201-207

[9] Structural basis for the activity of drugs that inhibit phosphodiesterases [J].

Card, GL ;

England, BP ;

Suzuki, Y ;

Fong, D ;

Powell, B ;

Lee, B ;

Luu, C ;

Tabrizizad, M ;

Gillette, S ;

Ibrahim, PN ;

Artis, DR ;

Bollag, G ;

Milburn, MV ;

Kim, SH ;

Schlessinger, J ;

Zhang, KYJ .

STRUCTURE, 2004, 12 (12) :2233-2247

[10] The role of tryptophan 1072 in human PDE3B inhibitor binding [J].

Chung, C ;

Varnerin, JP ;

Morin, NR ;

MacNeil, DJ ;

Singh, SB ;

Patel, S ;

Scapin, G ;

Van der Ploeg, LHT ;

Tota, MR .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 307 (04) :1045-1050

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