To extravasate the bloodstream at specific targets, circulating immune cells must activate their integrins to undergo rapid in situ modulation of affinity or avidity for their endothelial ligands. This activation involves specialized sub-second G-protein signal transduction triggered by endothelium-displayed chemo-attractants-primarily chemokines-and their cognate leukocyte-expressed G-protein-coupled receptors (GPCRs). Recently, we reported a rare autosomal-recessive leukocyte adhesion deficiency (LAD) syndrome associated with a defective ability of integrins to undergo GPCR-mediated stimulation at endothelial contacts. This LAD shows significant similarities to a group of integrin-activation syndromes reported in leukocytes and platelets. Here, the mechanisms by which GPCRs might regulate leukocyte and platelet integrins are outlined with respect to this new family of LAD cases. We propose to term this the LAD-III family.
机构:Imperial Canc Res Fund, Macrophage Lab, Lincolns Inn Fields Labs, Leukocyte Adhes Lab,Canc Res UK London Res Inst, London WC2A 3PX, England
McDowall, A
Inwald, D
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机构:Imperial Canc Res Fund, Macrophage Lab, Lincolns Inn Fields Labs, Leukocyte Adhes Lab,Canc Res UK London Res Inst, London WC2A 3PX, England
Inwald, D
Leitinger, B
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机构:Imperial Canc Res Fund, Macrophage Lab, Lincolns Inn Fields Labs, Leukocyte Adhes Lab,Canc Res UK London Res Inst, London WC2A 3PX, England
Leitinger, B
Jones, A
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机构:Imperial Canc Res Fund, Macrophage Lab, Lincolns Inn Fields Labs, Leukocyte Adhes Lab,Canc Res UK London Res Inst, London WC2A 3PX, England
Jones, A
Liesner, R
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机构:Imperial Canc Res Fund, Macrophage Lab, Lincolns Inn Fields Labs, Leukocyte Adhes Lab,Canc Res UK London Res Inst, London WC2A 3PX, England
Liesner, R
Klein, N
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机构:Imperial Canc Res Fund, Macrophage Lab, Lincolns Inn Fields Labs, Leukocyte Adhes Lab,Canc Res UK London Res Inst, London WC2A 3PX, England
Klein, N
Hogg, N
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Imperial Canc Res Fund, Macrophage Lab, Lincolns Inn Fields Labs, Leukocyte Adhes Lab,Canc Res UK London Res Inst, London WC2A 3PX, EnglandImperial Canc Res Fund, Macrophage Lab, Lincolns Inn Fields Labs, Leukocyte Adhes Lab,Canc Res UK London Res Inst, London WC2A 3PX, England
机构:Imperial Canc Res Fund, Macrophage Lab, Lincolns Inn Fields Labs, Leukocyte Adhes Lab,Canc Res UK London Res Inst, London WC2A 3PX, England
McDowall, A
Inwald, D
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h-index: 0
机构:Imperial Canc Res Fund, Macrophage Lab, Lincolns Inn Fields Labs, Leukocyte Adhes Lab,Canc Res UK London Res Inst, London WC2A 3PX, England
Inwald, D
Leitinger, B
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h-index: 0
机构:Imperial Canc Res Fund, Macrophage Lab, Lincolns Inn Fields Labs, Leukocyte Adhes Lab,Canc Res UK London Res Inst, London WC2A 3PX, England
Leitinger, B
Jones, A
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h-index: 0
机构:Imperial Canc Res Fund, Macrophage Lab, Lincolns Inn Fields Labs, Leukocyte Adhes Lab,Canc Res UK London Res Inst, London WC2A 3PX, England
Jones, A
Liesner, R
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h-index: 0
机构:Imperial Canc Res Fund, Macrophage Lab, Lincolns Inn Fields Labs, Leukocyte Adhes Lab,Canc Res UK London Res Inst, London WC2A 3PX, England
Liesner, R
Klein, N
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h-index: 0
机构:Imperial Canc Res Fund, Macrophage Lab, Lincolns Inn Fields Labs, Leukocyte Adhes Lab,Canc Res UK London Res Inst, London WC2A 3PX, England
Klein, N
Hogg, N
论文数: 0引用数: 0
h-index: 0
机构:
Imperial Canc Res Fund, Macrophage Lab, Lincolns Inn Fields Labs, Leukocyte Adhes Lab,Canc Res UK London Res Inst, London WC2A 3PX, EnglandImperial Canc Res Fund, Macrophage Lab, Lincolns Inn Fields Labs, Leukocyte Adhes Lab,Canc Res UK London Res Inst, London WC2A 3PX, England