ASC, Ipaf and Cryopyrin/Nalp3: bona fide intracellular adapters of the caspase-1 inflammasome

被引：73

作者：

Mariathasan, Sanjeev ^{[1
]}

机构：

[1] Genentech Inc, Dept Translat Oncol, San Francisco, CA 94080 USA

来源：

MICROBES AND INFECTION | 2007年 / 9卷 / 05期

关键词：

ASC; Ipaf; cryopyrin; Nalp3; inflammasome;

D O I：

10.1016/j.micinf.2007.01.017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

The adapter molecules ASC, lpaf and Cryopyrin/Nalp3 have each been proposed to regulate caspase-1 within a multi-protein complex called the "inflammasome". Activation of caspase-1 leads to the cleavage and activation of pro-inflammatory cytokines such as interleukin (IL)-1 beta and IL-18. The analysis of mice deficient in ASC, lpaf and Cryopyrin/Nalp3 has revealed that the inflammasome is a dynamic entity that is assembled from different adapters in a stimulus-dependent manner. (c) 2007 Elsevier Masson SAS. All rights reserved.

引用

页码：664 / 671

页数：8

共 55 条

[1]

NALP3 forms an IL-lβ-Processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder [J].

Agostini, L ;

Martinon, F ;

Burns, K ;

McDermott, MF ;

Hawkins, PN ;

Tschopp, J .

IMMUNITY, 2004, 20 (03) :319-325

[2]

Phospholipases C and A2 control lysosome-mediated IL-1β secretion:: Implications for inflammatory processes [J].

Andrei, C ;

Margiocco, P ;

Poggi, A ;

Lotti, LV ;

Torrisi, MR ;

Rubartelli, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (26) :9745-9750

[3]

Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin [J].

Boyden, ED ;

Dietrich, WF .

NATURE GENETICS, 2006, 38 (02) :240-244

[4]

New insights into the mechanism of IL-1β maturation [J].

Burns, K ;

Martinon, F ;

Tschopp, J .

CURRENT OPINION IN IMMUNOLOGY, 2003, 15 (01) :26-30

[5]

A bacterial invasin induces macrophage apoptosis by binding directly to ICE [J].

Chen, YJ ;

Smith, MR ;

Thirumalai, K ;

Zychlinsky, A .

EMBO JOURNAL, 1996, 15 (15) :3853-3860

[6]

Conway KE, 2000, CANCER RES, V60, P6236

[7]

Bacterial invasion: The paradigms of enteroinvasive pathogens [J].

Cossart, P ;

Sansonetti, PJ .

SCIENCE, 2004, 304 (5668) :242-248

[8]

Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses [J].

Damiano, JS ;

Oliveira, V ;

Welsh, K ;

Reed, JC .

BIOCHEMICAL JOURNAL, 2004, 381 (01) :213-219

[9]

Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila [J].

Diez, E ;

Lee, SH ;

Gauthier, S ;

Yaraghi, Z ;

Tremblay, M ;

Vidal, S ;

Gros, P .

NATURE GENETICS, 2003, 33 (01) :55-60

[10]

Interleukin-18 [J].

Dinarello, CA .

METHODS-A COMPANION TO METHODS IN ENZYMOLOGY, 1999, 19 (01) :121-132

← 1 2 3 4 5 6 →