A potential proteasome-interacting motif within the ubiquitin-like domain of parkin and other proteins

被引：51

作者：

Upadhya, SC ^{[1
]}

Hegde, AN ^{[1
]}

机构：

[1] Wake Forest Univ, Dept Neurobiol & Anat, Winston Salem, NC 27157 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2003年 / 28卷 / 06期

关键词：

D O I：

10.1016/S0968-0004(03)00092-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Parkin and other unrelated proteins contain a ubiquitin-like domain (UbLD). This article describes a motif that might be important in the interaction of UbLD-containing proteins (UbLPs) with the proteasome. The proteasome-interacting motif, which is conserved in a subset of UbLPs, such as parkin, Rad23 and several transcription factors, is likely to enable the UbLPs to form a complex with the proteasome for proteolysis or the recently discovered non-proteolytic functions of the proteasome.

引用

页码：280 / 283

页数：4

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