Telomere and telomerase dynamics in human cells

被引：26

作者：

Hahn, WC

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[3] Harvard Univ, Broad Inst, Cambridge, MA 02139 USA

[4] MIT, Cambridge, MA 02139 USA

来源：

CURRENT MOLECULAR MEDICINE | 2005年 / 5卷 / 02期

关键词：

D O I：

10.2174/1566524053586572

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Accumulating evidence now implicates telomeres and telomerase as critical regulators genomic stability and replicative lifespan in mammalian cells. Disruption of telomere maintenance and/or telomerase expression contributes to the etiology of some degenerative diseases and may participate in the process of aging. Although telomere dysfunction and aberrant telomerase expression clearly play important roles in cancer development, the contribution of telomere biology to cancer is complex and involves both positive and negative influences on tumor development. Indeed, recent work from several laboratories suggests additional roles for telomeres and telomerase in both normal and malignant, physiology. Understanding the complexity of telomere biology will provide further insights into chromosome biology in both normal and malignant cells.

引用

收藏

页码：227 / 231

页数：5

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