Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells

被引:113
作者
Allsopp, RC [1 ]
Morin, GB
Horner, JW
DePinho, R
Harley, CB
Weissman, IL
机构
[1] Stanford Univ, Beckman Ctr, Dept Pathol, Sch Med, Stanford, CA 94305 USA
[2] Geron Corp, Menlo Pk, CA USA
[3] Harvard Univ, Dana Farber Canc Inst, Boston, MA 02115 USA
关键词
D O I
10.1038/nm0403-369
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:369 / U6
页数:4
相关论文
共 9 条
  • [1] Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells
    Allsopp, RC
    Cheshier, S
    Weissman, IL
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (08) : 917 - 924
  • [2] Extension of life-span by introduction of telomerase into normal human cells
    Bodnar, AG
    Ouellette, M
    Frolkis, M
    Holt, SE
    Chiu, CP
    Morin, GB
    Harley, CB
    Shay, JW
    Lichtsteiner, S
    Wright, WE
    [J]. SCIENCE, 1998, 279 (5349) : 349 - 352
  • [3] LOSS OF STEM-CELL REPOPULATING ABILITY UPON TRANSPLANTATION - EFFECTS OF DONOR AGE, CELL NUMBER, AND TRANSPLANTATION PROCEDURE
    HARRISON, DE
    ASTLE, CM
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1982, 156 (06) : 1767 - 1779
  • [4] The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability
    Hemann, MT
    Strong, MA
    Hao, LY
    Greider, CW
    [J]. CELL, 2001, 107 (01) : 67 - 77
  • [5] Heterogeneity in telomere length of human chromosomes
    Lansdorp, PM
    Verwoerd, NP
    vandeRijke, FM
    Dragowska, V
    Little, MT
    Dirks, RW
    Raap, AL
    Tanke, HJ
    [J]. HUMAN MOLECULAR GENETICS, 1996, 5 (05) : 685 - 691
  • [6] Telomerase activity in hematopoietic cells is associated with self-renewal potential
    Morrison, SJ
    Prowse, KR
    Ho, P
    Weissman, IL
    [J]. IMMUNITY, 1996, 5 (03) : 207 - 216
  • [7] Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells
    Samper, E
    Fernández, P
    Eguía, R
    Martín-Rivera, L
    Bernad, A
    Blasco, MA
    Aracil, M
    [J]. BLOOD, 2002, 99 (08) : 2767 - 2775
  • [8] Cellular senescence: Mitotic clock or culture shock?
    Sherr, CJ
    DePinho, RA
    [J]. CELL, 2000, 102 (04) : 407 - 410
  • [9] EVIDENCE FOR A MITOTIC CLOCK IN HUMAN HEMATOPOIETIC STEM-CELLS - LOSS OF TELOMERIC DNA WITH AGE
    VAZIRI, H
    DRAGOWSKA, W
    ALLSOPP, RC
    THOMAS, TE
    HARLEY, CB
    LANSDORP, PM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (21) : 9857 - 9860