Synthesis of functionalized nitroarylmagnesium halides via an iodine-magnesium exchange

被引:47
作者
Sapountzis, L [1 ]
Dube, H [1 ]
Lewis, R [1 ]
Gommermann, N [1 ]
Knochel, P [1 ]
机构
[1] Univ Munich, Dept Chem, D-81377 Munich, Germany
关键词
D O I
10.1021/jo048132o
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Various nitro-substituted aryl and heteroaryl iodides undergo an iodine-magnesium exchange reaction when treated with PhMgCl leading to nitro-containing magnesium organometallics. These Grignard reagents display an excellent stability at temperatures below -40 degrees C and do not undergo electron-transfer reactions. They react as expected with various electrophiles.
引用
收藏
页码:2445 / 2454
页数:10
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