Minimal analytical characterization of engineered nanomaterials needed for hazard assessment in biological matrices

被引：109

作者：

Bouwmeester, Hans ^{[1
]}

Lynch, Iseult ^{[2
]}

Marvin, Hans J. P. ^{[1
]}

Dawson, Kenneth A. ^{[2
]}

Berges, Markus ^{[3
]}

Braguer, Diane ^{[4
]}

Byrne, Hugh J. ^{[5
]}

Casey, Alan ^{[5
]}

Chambers, Gordon ^{[5
]}

Clift, Martin J. D. ^{[6
]}

Elia, Giuliano ^{[11
]}

Fernandes, Teresa F. ^{[7
]}

Fjellsbo, Lise B. ^{[8
]}

Hatto, Peter

Juillerat, Lucienne ^{[9
]}

Klein, Christoph ^{[10
]}

Kreyling, Wolfgang G. ^{[14
]}

Nickel, Carmen ^{[13
]}

Riediker, Michael ^{[12
]}

Stone, Vicki ^{[7
]}

机构：

[1] Wageningen UR, RIKILT Inst food Safety, NL-6700 AE Wageningen, Netherlands

[2] Univ Coll Dublin, Sch Chem & Chem Biol, Ctr BioNano Interact, Dublin, Ireland

[3] Inst Occupat Safety & Hlth, Div Hazardous Subst Handling Protect Measures 3, Sub Div Exposure Assessment, St Augustin, Germany

[4] Univ Mediterranee, Fac Pharm, INSERM, UMR911, Marseille, France

[5] Dublin Inst Technol, Focas Inst, Dublin 8, Ireland

[6] Univ Bern, Div Histol, Inst Anat, CH-3012 Bern, Switzerland

[7] Edinburgh Napier Univ, Sch Life Sci, Edinburgh, Midlothian, Scotland

[8] NILU Norwegian Inst Air Res, Kjeller, Norway

[9] Inst Univ Pathol CHUV UNIL, Lausanne, Switzerland

[10] European Commiss JRC, Inst Hlth & Consumer Protect IHCP Nanotechnol & M, Ispra, Italy

[11] UCD Conway Inst, Dublin, Ireland

[12] Inst Work & Hlth, Lausanne, Switzerland

[13] Inst Energie & Umwelttech eV, IUTA, Air Qual & Sustainable Nanotechnol Unit, Duisburg, Germany

[14] Helmholtz Zentrum Munchen, Focus Network Nanoparticles & Hlth, Inst Inhalat Biol, Neuherberg, Germany

来源：

NANOTOXICOLOGY | 2011年 / 5卷 / 01期

关键词：

Nanomaterials; characterization; metrics; nanotoxicology; hazard assessment; WALLED CARBON NANOTUBES; IN-VITRO; SURFACE-AREA; RESEARCH STRATEGIES; SAFETY EVALUATION; OXIDATIVE STRESS; PROTEIN CORONA; NANOPARTICLES; ULTRAFINE; PARTICLES;

D O I：

10.3109/17435391003775266

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

This paper presents the outcomes from a workshop of the European Network on the Health and Environmental Impact of Nanomaterials (NanoImpactNet). During the workshop, 45 experts in the field of safety assessment of engineered nanomaterials addressed the need to systematically study sets of engineered nanomaterials with specific metrics to generate a data set which would allow the establishment of dose-response relations. The group concluded that international cooperation and worldwide standardization of terminology, reference materials and protocols are needed to make progress in establishing lists of essential metrics. High quality data necessitates the development of harmonized study approaches and adequate reporting of data. Priority metrics can only be based on well-characterized dose-response relations derived from the systematic study of the bio-kinetics and bio-interactions of nanomaterials at both organism and (sub)-cellular levels. In addition, increased effort is needed to develop and validate analytical methods to determine these metrics in a complex matrix.

引用

页码：1 / 11

页数：11

共 45 条

[1]

[Anonymous], 2004, Nanoscience and nanotechnologies: opportunities and uncertainties

[2] Chemical stability of metallic nanoparticles: A parameter controlling their potential cellular toxicity in vitro [J].

Auffan, Melanie ;

Rose, Jerome ;

Wiesner, Mark R. ;

Bottero, Jean-Yves .

ENVIRONMENTAL POLLUTION, 2009, 157 (04) :1127-1133

[3] Optimized dispersion of nanoparticles for biological in vitro and in vivo studies [J].

Bihari, Peter ;

Vippola, Minnamari ;

Schultes, Stephan ;

Praetner, Marc ;

Khandoga, Alexander G. ;

Reichel, Christoph A. ;

Coester, Conrad ;

Tuomi, Timo ;

Rehberg, Markus ;

Krombach, Fritz .

PARTICLE AND FIBRE TOXICOLOGY, 2008, 5 (1)

[4] Review of health safety aspects of nanotechnologies in food production [J].

Bouwmeester, Hans ;

Dekkers, Susan ;

Noordam, Maryvon Y. ;

Hagens, Werner I. ;

Bulder, Astrid S. ;

de Heer, Cees ;

ten Voorde, Sandra E. C. G. ;

Wijnhoven, Susan W. P. ;

Marvin, Hans J. P. ;

Sips, Adrienne J. A. M. .

REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2009, 53 (01) :52-62

[5] Nanomaterial characterization: considerations and needs for hazard assessment and safety evaluation [J].

Boverhof, Darrell R. ;

David, Raymond M. .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2010, 396 (03) :953-961

[6] An in vitro study of the potential of carbon nanotubes and nanofibres to induce inflammatory mediators and frustrated phagocytosis [J].

Brown, D. M. ;

Kinloch, I. A. ;

Bangert, U. ;

Windle, A. H. ;

Walter, D. M. ;

Walker, G. S. ;

Scotchford, C. A. ;

Donaldson, K. ;

Stone, V. .

CARBON, 2007, 45 (09) :1743-1756

[7] Size-dependent proinflammatory effects of ultrafine polystyrene particles: A role for surface area and oxidative stress in the enhanced activity of ultrafines [J].

Brown, DM ;

Wilson, MR ;

MacNee, W ;

Stone, V ;

Donaldson, K .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2001, 175 (03) :191-199

[8] Spectroscopic analysis confirms the interactions between single walled carbon nanotubes and various dyes commonly used to assess cytotoxicity [J].

Casey, A. ;

Herzog, E. ;

Davoren, M. ;

Lyng, F. M. ;

Byrne, H. J. ;

Chambers, G. .

CARBON, 2007, 45 (07) :1425-1432

[9] Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles [J].

Cedervall, Tommy ;

Lynch, Iseult ;

Lindman, Stina ;

Berggard, Tord ;

Thulin, Eva ;

Nilsson, Hanna ;

Dawson, Kenneth A. ;

Linse, Sara .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (07) :2050-2055

[10] Emerging trends of nanoparticles application in food technology: Safety paradigms [J].

Das, Mukul ;

Saxena, Neha ;

Dwivedi, Premendra D. .

NANOTOXICOLOGY, 2009, 3 (01) :10-18

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