Chemical stability of metallic nanoparticles: A parameter controlling their potential cellular toxicity in vitro

被引：412

作者：

Auffan, Melanie ^{[1
]}

Rose, Jerome ^{[2
,3
]}

Wiesner, Mark R. ^{[1
]}

Bottero, Jean-Yves ^{[2
,3
]}

机构：

[1] Duke Univ, Dept Civil & Environm Engn, Durham, NC 27708 USA

[2] Aix Marseille Univ, CNRS, UMR 6635, CEREGE, F-13545 Aix En Provence, France

[3] ECOREV, F-13545 Aix En Provence, France

来源：

ENVIRONMENTAL POLLUTION | 2009年 / 157卷 / 04期

基金：

美国国家科学基金会;

关键词：

Redox; Metallic; Nanoparticles; Toxicity; Oxidative stress; CERIUM OXIDE NANOPARTICLES; ENGINEERED NANOPARTICLES; ESCHERICHIA-COLI; OXIDATIVE STRESS; CYTOTOXICITY; FIBROBLASTS; SILVER; CELLS; SIZE; PARTICLES;

D O I：

10.1016/j.envpol.2008.10.002

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The level of production of nanoparticles will inevitably lead to their appearance in air, water, soils, and organisms. A theoretical framework that relates properties of nanoparticles to their biological effects is needed to identify possible risks to human health and the environment. This paper considers the properties of dispersed metallic nanoparticles and highlights the relationship between the chemical stability of these nanoparticles and their in vitro toxicity. Analysis of published data suggests that chemically stable metallic nanoparticles have no significant cellular toxicity, whereas nanoparticles able to be oxidized, reduced or dissolved are cytotoxic and even genotoxic for cellular organisms. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1127 / 1133

页数：7

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