Chemical stability of metallic nanoparticles: A parameter controlling their potential cellular toxicity in vitro

被引：412

作者：

Auffan, Melanie ^{[1
]}

Rose, Jerome ^{[2
,3
]}

Wiesner, Mark R. ^{[1
]}

Bottero, Jean-Yves ^{[2
,3
]}

机构：

[1] Duke Univ, Dept Civil & Environm Engn, Durham, NC 27708 USA

[2] Aix Marseille Univ, CNRS, UMR 6635, CEREGE, F-13545 Aix En Provence, France

[3] ECOREV, F-13545 Aix En Provence, France

来源：

ENVIRONMENTAL POLLUTION | 2009年 / 157卷 / 04期

基金：

美国国家科学基金会;

关键词：

Redox; Metallic; Nanoparticles; Toxicity; Oxidative stress; CERIUM OXIDE NANOPARTICLES; ENGINEERED NANOPARTICLES; ESCHERICHIA-COLI; OXIDATIVE STRESS; CYTOTOXICITY; FIBROBLASTS; SILVER; CELLS; SIZE; PARTICLES;

D O I：

10.1016/j.envpol.2008.10.002

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The level of production of nanoparticles will inevitably lead to their appearance in air, water, soils, and organisms. A theoretical framework that relates properties of nanoparticles to their biological effects is needed to identify possible risks to human health and the environment. This paper considers the properties of dispersed metallic nanoparticles and highlights the relationship between the chemical stability of these nanoparticles and their in vitro toxicity. Analysis of published data suggests that chemically stable metallic nanoparticles have no significant cellular toxicity, whereas nanoparticles able to be oxidized, reduced or dissolved are cytotoxic and even genotoxic for cellular organisms. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1127 / 1133

页数：7

共 93 条

[21] The role of free radicals in the toxic and inflammatory effects of four different ultrafine particle types [J].

Dick, CAJ ;

Brown, DM ;

Donaldson, K ;

Stone, V .

INHALATION TOXICOLOGY, 2003, 15 (01) :39-52

[22] Size-dependent melting of silica-encapsulated gold nanoparticles [J].

Dick, K ;

Dhanasekaran, T ;

Zhang, ZY ;

Meisel, D .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (10) :2312-2317

[23]

Elechiguerra Jose Luis, 2005, J Nanobiotechnology, V3, P6

[24] COMPUTATION OF EH-PH DIAGRAMS FOR M-S-H2O SYSTEMS - A NEW APPROACH [J].

ELRAGHY, SM ;

ELDEMERDASH, MF .

JOURNAL OF THE ELECTROCHEMICAL SOCIETY, 1989, 136 (12) :3647-3654

[25]

Feng QL, 2000, J BIOMED MATER RES, V52, P662, DOI 10.1002/1097-4636(20001215)52:4<662::AID-JBM10>3.0.CO

[26]

2-3

[27]

Fond AM, 2006, NANOMATERIALS TOXICI, P3

[28] C60 in water:: Nanocrystal formation and microbial response [J].

Fortner, JD ;

Lyon, DY ;

Sayes, CM ;

Boyd, AM ;

Falkner, JC ;

Hotze, EM ;

Alemany, LB ;

Tao, YJ ;

Guo, W ;

Ausman, KD ;

Colvin, VL ;

Hughes, JB .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2005, 39 (11) :4307-4316

[29] Comparative toxicity of nanoparticulate ZnO, bulk ZnO, and ZnCl2 to a freshwater microalga (Pseudokirchneriella subcapitata):: The importance of particle solubility [J].

Franklin, Natasha M. ;

Rogers, Nicola J. ;

Apte, Simon C. ;

Batley, Graeme E. ;

Gadd, Gerald E. ;

Casey, Philip S. .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2007, 41 (24) :8484-8490

[30] Imaging of surface oxygen atoms and their defect structures on CeO2(111) by noncontact atomic force microscopy [J].

Fukui, K ;

Namai, Y ;

Iwasawa, Y .

APPLIED SURFACE SCIENCE, 2002, 188 (3-4) :252-256

← 1 2 3 4 5 6 7 8 9 10 →