Generation of isogenic pluripotent stem cells

被引：23

作者：

Byrne, James A. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Inst Stem Cell Biol & Regenerat Med, Dept Obstet & Gynecol,Ctr Human Embryon Stem Cell, Palo Alto, CA 94304 USA

来源：

HUMAN MOLECULAR GENETICS | 2008年 / 17卷

关键词：

D O I：

10.1093/hmg/ddn053

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ability to reprogram somatic cell nuclei back into a pluripotent epigenetic state provides exciting new possibilities for in vitro research and cell transplantation therapy. There has been a significant quantity of recent research studies demonstrating that this epigenetic reprogramming process is possible with human and non-human primate somatic cells. In this review, various methodologies for reprogramming primate somatic cells into pluripotent stem cells are examined, epigenetic reprogramming following somatic cell nuclear transfer and normal primate embryonic development is compared, and future potential methods to induce direct reprogramming without using genetic modification are discussed.

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页码：R37 / R41

页数：5

相关论文

共 35 条

[1] Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice [J].

Barberi, T ;

Klivenyi, P ;

Calingasan, NY ;

Lee, H ;

Kawamata, H ;

Loonam, K ;

Perrier, AL ;

Bruses, J ;

Rubio, ME ;

Topf, N ;

Tabar, V ;

Harrison, NL ;

Beal, MF ;

Moore, MAS ;

Studer, L .

NATURE BIOTECHNOLOGY, 2003, 21 (10) :1200-1207

[2]

BYRNE J, 2007, AUSTR INT SOC STEM C

[3] Producing primate embryonic stem cells by somatic cell nuclear transfer [J].

Byrne, J. A. ;

Pedersen, D. A. ;

Clepper, L. L. ;

Nelson, M. ;

Sanger, W. G. ;

Gokhale, S. ;

Wolf, D. P. ;

Mitalipov, S. M. .

NATURE, 2007, 450 (7169) :497-U3

[4] Nuclei of adult mammalian somatic cells are directly reprogrammed to oct-4 stem cell gene expression by amphibian oocytes [J].

Byrne, JA ;

Simonsson, S ;

Western, PS ;

Gurdon, JB .

CURRENT BIOLOGY, 2003, 13 (14) :1206-1213

[5] Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells [J].

Cowan, CA ;

Atienza, J ;

Melton, DA ;

Eggan, K .

SCIENCE, 2005, 309 (5739) :1369-1373

[6] The unique transcriptome through day 3 of human preimplantation development [J].

Dobson, AT ;

Raja, R ;

Abeyta, MJ ;

Taylor, T ;

Shen, S ;

Haqq, C ;

Pera, RAR .

HUMAN MOLECULAR GENETICS, 2004, 13 (14) :1461-1470

[7] Rabbit embryonic stem cell lines derived from fertilized, parthenogenetic or somatic cell nuclear transfer embryos [J].

Fang, Zhen F. ;

Gai, Hui ;

Huang, You Z. ;

Li, Shan G. ;

Chen, Xue J. ;

Shi, Jian J. ;

Wu, Li ;

Liu, Ailian ;

Xu, Ping ;

Sheng, Hui Z. .

EXPERIMENTAL CELL RESEARCH, 2006, 312 (18) :3669-3682

[8] DNA methylation pattern in human zygotes and developing embryos [J].

Fulka, H ;

Mrazek, M ;

Tepla, O ;

Fulka, J .

REPRODUCTION, 2004, 128 (06) :703-708

[9] Oct-3/4 is a dose-dependent oncogenic fate determinant [J].

Gidekel, S ;

Pizov, G ;

Bergman, Y ;

Pikarsky, E .

CANCER CELL, 2003, 4 (05) :361-370

[10]

GURDON JB, 1962, J EMBRYOL EXP MORPH, V10, P622

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