Ultra Magnetic Liposomes for MR Imaging, Targeting, and Hyperthermia

被引：153

作者：

Bealle, Gaelle ^{[1
]}

Di Corato, Riccardo ^{[2
]}

Kolosnjaj-Tabi, Jelena ^{[2
,3
]}

Dupuis, Vincent ^{[1
]}

Clement, Olivier ^{[3
]}

Gazeau, Florence ^{[2
]}

Wilhelm, Claire ^{[2
]}

Menager, Christine ^{[1
]}

机构：

[1] Univ Paris 06, CNRS, ESPCI, Lab PECSA,UMR 7195, F-75252 Paris 05, France

[2] Univ Paris Diderot, CNRS, Lab Mat Syst Complexes MSC, UMR 7057, F-75205 Paris 13, France

[3] Univ Paris 05, INSERM, U970, Paris Cardiovasc Res Ctr PARCC, F-75015 Paris, France

来源：

LANGMUIR | 2012年 / 28卷 / 32期

关键词：

PEG-GRAFTED IMMUNOMAGNETOLIPOSOMES; FE3O4; NANOPARTICLES; CONTROLLED-RELEASE; CONTRAST AGENTS; RESONANCE; MAGNETOLIPOSOMES; PARTICLES; DESIGN;

D O I：

10.1021/la3024716

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Magnetic liposomes offer opportunities as theranostic systems. The prerequisite for efficient imaging, tissue targeting or hyperthermia is high magnetic load of these vesicles. Here we describe the preparation of Ultra Magnetic Liposomes (UMLs), which may encapsulate iron oxide nanoparticles in a volume fraction of up to 30%. This remarkable magnetic charge provides UMLs with high magnetic mobilities, MRI relaxivities, and heating capacities for magnetic hyperthermia. Moreover, these UMLs are rapidly and efficiently internalized by cultured tumor cells and, when they are administered to mice, they can be vectorized to tumors by an external magnet.

引用

页码：11843 / 11851

页数：9

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