Triggered Release from Liposomes through Magnetic Actuation of Iron Oxide Nanoparticle Containing Membranes

被引：310

作者：

Amstad, Esther ^{[1
]}

Kohlbrecher, Joachim ^{[2
]}

Mueller, Elisabeth ^{[3
]}

Schweizer, Thomas ^{[4
]}

Textor, Marcus ^{[1
]}

Reimhult, Erik ^{[1
,5
]}

机构：

[1] ETH, Surface Sci & Technol Lab, CH-8093 Zurich, Switzerland

[2] Paul Scherrer Inst, Neutron Scattering Lab, CH-5232 Villigen, Switzerland

[3] EMEZ, CH-8093 Zurich, Switzerland

[4] ETH, Dept Mat, CH-8093 Zurich, Switzerland

[5] Univ Nat Resources & Life Sci BOKU, Dept Nanobiotechnol, A-1190 Vienna, Austria

来源：

NANO LETTERS | 2011年 / 11卷 / 04期

关键词：

Stealth liposorne; superparamagnetic iron oxide nanopartide; triggered release; drug delivery vehicle; nanoreactor; palmityl-nitroDOPA; TEMPERATURE; MAGNETOLIPOSOMES; NANOCONTAINERS; DESIGN; SYSTEM; TUMOR;

D O I：

10.1021/nl2001499

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The ideal nanoscale drug delivery vehicle allows control over the released dose in space and time We demonstrate that this can be achieved by stealth liposomes comprising self assembled superpararnagnetic iron oxide nanoparticles (NPs) individually stabilized with palmityl-nitroDOPA incorporated in the lipid membrane. Alternating magnetic fields were used to control timing and dose of repeatedly released cargo from such vesicles by locally heating the membrane, which changed its permeability without major effects on the environment.

引用

页码：1664 / 1670

页数：7

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