Therapeutic potential and strategies for inhibiting tumor necrosis factor-α

被引:178
作者
Newton, RC
Decicco, CP
机构
[1] Dupont Merck Pharmaceut Co, Expt Stn, Dept Inflammatory Dis Res, Wilmington, DE 19880 USA
[2] Dupont Merck Pharmaceut Co, Expt Stn, Dept Chem & Phys Sci, Wilmington, DE 19880 USA
关键词
D O I
10.1021/jm980541n
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:2295 / 2314
页数:20
相关论文
共 248 条
[11]   CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES - FUNCTIONAL IMPLICATIONS OF MULTIPLE ISOFORMS [J].
BEAVO, JA .
PHYSIOLOGICAL REVIEWS, 1995, 75 (04) :725-748
[12]   Matrix metalloproteinase inhibitors 1998 [J].
Beckett, RP ;
Whittaker, M .
EXPERT OPINION ON THERAPEUTIC PATENTS, 1998, 8 (03) :259-282
[13]   FIBRONECTIN FRAGMENTS STIMULATE TUMOR-NECROSIS-FACTOR SECRETION BY HUMAN MONOCYTES [J].
BEEZHOLD, DH ;
PERSONIUS, C .
JOURNAL OF LEUKOCYTE BIOLOGY, 1992, 51 (01) :59-64
[14]   An essential role for NF-kappa B in preventing TNF-alpha-induced cell death [J].
Beg, AA ;
Baltimore, D .
SCIENCE, 1996, 274 (5288) :782-784
[15]   IκBα degradation and nuclear factor-κB DNA binding are insufficient for interleukin-1β and tumor necrosis factor-α-induced κB-dependent transcription -: Requirement for an additional activation pathway [J].
Bergmann, M ;
Hart, L ;
Lindsay, M ;
Barnes, PJ ;
Newton, R .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (12) :6607-6610
[16]  
BEUTLER B, 1992, TUMOR NECROSIS FACTO, P561
[17]   MATRIX METALLOPROTEINASES - A REVIEW [J].
BIRKEDALHANSEN, H ;
MOORE, WGI ;
BODDEN, MK ;
WINDSOR, LJ ;
BIRKEDALHANSEN, B ;
DECARLO, A ;
ENGLER, JA .
CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE, 1993, 4 (02) :197-250
[18]   A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells [J].
Black, RA ;
Rauch, CT ;
Kozlosky, CJ ;
Peschon, JJ ;
Slack, JL ;
Wolfson, MF ;
Castner, BJ ;
Stocking, KL ;
Reddy, P ;
Srinivasan, S ;
Nelson, N ;
Boiani, N ;
Schooley, KA ;
Gerhart, M ;
Davis, R ;
Fitzner, JN ;
Johnson, RS ;
Paxton, RJ ;
March, CJ ;
Cerretti, DP .
NATURE, 1997, 385 (6618) :729-733
[19]   Agents that block TNF-alpha synthesis or activity [J].
Black, RA ;
Bird, TA ;
Mohler, KM .
ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 32, 1997, 32 :241-250
[20]   CD95 (Fas/APO-1) induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase [J].
Boesen-de Cock, JGR ;
Tepper, AD ;
de Vries, E ;
van Blitterswijk, WJ ;
Borst, J .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (13) :7560-7565