How Can Proteins Enter the Interior of a MOF? Investigation of Cytochrome c Translocation into a MOF Consisting of Mesoporous Cages with Microporous Windows

被引：314

作者：

Chen, Yao ^{[1
]}

Lykourinou, Vasiliki ^{[1
]}

Vetromile, Carissa ^{[1
]}

Tran Hoang ^{[1
]}

Ming, Li-June ^{[1
]}

Larsen, Randy W. ^{[1
]}

Ma, Shengqian ^{[1
]}

机构：

[1] Univ S Florida, Dept Chem, Tampa, FL 33620 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 32期

关键词：

METAL-ORGANIC FRAMEWORKS; MITOCHONDRIAL; FLUORESCENCE;

D O I：

10.1021/ja305144x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

It has been demonstrated for the first time that the heme protein cytochrome c (Cyt c) can enter the interior of a MOF despite the larger molecular dimension of the protein relative to the access pore sizes. Mechanistic studies suggest that the Cyt c molecules must undergo a significant conformational change during translocation into the MOF interior through the relatively small nanopores.

引用

页码：13188 / 13191

页数：4

共 38 条

[1]

[Anonymous], 2009, CHEM SOC REV, V38, P1213

[2]

Chen Y, 2012, PREPR S AM CHEM SOC, V57, P1000

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