Molecular mechanisms of photocarcinogenesis

被引：103

作者：

Matsumura, Y ^{[1
]}

Ananthaswamy, HN ^{[1
]}

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2002年 / 7卷

关键词：

photocarcinogenesis; ultraviolet; skin cancer; DNA repair; p53; Ptc. hedgehog pathway; p16(INK4a); p19(ARF); ras; review;

D O I：

10.2741/matsumur

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Photocarcinogenesis represents the accumulation of genetic changes as well as immune system modulation, which ultimately lead to the development of skin cancers. The recent advances in molecular and cellular biology have clarified the mechanisms of photocarcinogenesis, including the formation of DNA photoproducts, DNA repair, mutation of proto-oncogenes and tumor suppressor genes, and UV-induced immunosuppression. The understanding and further investigation of photocarcinogenesis is critical to the development of effective prevention and intervention strategies for human skin cancer.

引用

页码：D765 / D783

页数：19

共 227 条

[11] ROLE OF PROTOONCOGENE ACTIVATION IN CARCINOGENESIS [J].

ANDERSON, MW ;

REYNOLDS, SH ;

YOU, M ;

MARONPOT, RM .

ENVIRONMENTAL HEALTH PERSPECTIVES, 1992, 98 :13-24

[12]

ARMSTRONG BK, 1994, CANCER SURV, V20, P219

[13] Identification of mutations in the human PATCHED gene in sporadic basal cell carcinomas and in patients with the basal cell nevus syndrome [J].

Aszterbaum, M ;

Rothman, A ;

Johnson, RL ;

Fisher, M ;

Xie, JW ;

Bonifas, JM ;

Zhang, XL ;

Scott, MP ;

Epstein, EH .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1998, 110 (06) :885-888

[14]

Autier P, 1998, INT J CANCER, V77, P533, DOI 10.1002/(SICI)1097-0215(19980812)77:4<533::AID-IJC10>3.0.CO

[15]

2-7

[16] Proteolysis that is inhibited by Hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor [J].

AzaBlanc, P ;

RamirezWeber, FA ;

Laget, MP ;

Schwartz, C ;

Kornberg, TB .

CELL, 1997, 89 (07) :1043-1053

[17] RAS GENES [J].

BARBACID, M .

ANNUAL REVIEW OF BIOCHEMISTRY, 1987, 56 :779-827

[18] Cell surface trafficking of Fas: A rapid mechanism of p53-mediated apoptosis [J].

Bennett, M ;

Macdonald, K ;

Chan, SW ;

Luzio, JP ;

Simari, R ;

Weissberg, P .

SCIENCE, 1998, 282 (5387) :290-293

[19] ANALYSIS OF THE GENE CODING FOR THE MURINE CELLULAR TUMOR-ANTIGEN P53 [J].

BIENZ, B ;

ZAKUTHOURI, R ;

GIVOL, D ;

OREN, M .

EMBO JOURNAL, 1984, 3 (09) :2179-2183

[20] RELATIONSHIP BETWEEN GENE AMPLIFICATION AND CHROMOSOMAL DEVIATIONS IN MALIGNANT HUMAN GLIOMAS [J].

BIGNER, SH ;

WONG, AJ ;

MARK, J ;

MUHLBAIER, LH ;

KINZLER, KW ;

VOGELSTEIN, B ;

BIGNER, DD .

CANCER GENETICS AND CYTOGENETICS, 1987, 29 (01) :165-170

← 1 2 3 4 5 6 7 8 9 10 →