NMR chemical shift methods for binding constant determination of an organic anion and α-cyclodextrin

被引：21

作者：

Funasaki, N ^{[1
]}

Ishikawa, S ^{[1
]}

Neya, S ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Yamashima Ku, Kyoto 6078414, Japan

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 2002年 / 75卷 / 04期

关键词：

D O I：

10.1246/bcsj.75.719

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Internal reference compounds suitable for proton chemical shift measurements of organic anions in deuterium oxide solutions are proposed and used to determine the binding constant of sodium hexane-1-sulfonate (SHS) and alpha-cyclodextrin (alpha-CD). The chemical shift of the methyl proton of sodium methyl sulfate (MeS), referred to external sodium 4,4-dimethyl-4-silapentane-1-sulfonate (DSS), changes linearly with the alpha-CD concentration, because of the volume magnetic susceptibility effect. The chemical shifts of the SHS methyl proton, referred to external DSS and corrected for this magnetic susceptibility effect, as well as referred to internal MeS and methanol (MeOH), provide reliable binding constants of SHS and alpha-CD. Therefore, MeS and MeOH are appropriate internal standards for organic anions. The present results serve not only for choosing appropriate internal references and the internal or external standard method for chemical shift measurements but also for correcting the chemical shift referred to an external standard.

引用

页码：719 / 723

页数：5

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