Hypoxia-Sensitive Fluorescent Probes for in Vivo Real-Time Fluorescence Imaging of Acute Ischemia

被引：336

作者：

Kiyose, Kazuki ^{[1
,2
]}

Hanaoka, Kenjiro ^{[1
,2
]}

Oushiki, Daihi ^{[1
,2
]}

Nakamura, Tomomi ^{[3
]}

Kajimura, Mayumi ^{[3
]}

Suematsu, Makoto ^{[3
]}

Nishimatsu, Hiroaki ^{[4
]}

Yamane, Takehiro ^{[1
,2
]}

Terai, Takuya ^{[1
,2
]}

Hirata, Yasunobu ^{[2
,4
]}

Nagano, Tetsuo ^{[1
,2
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

[2] JST Agcy, CREST, Kawaguchi, Saitama, Japan

[3] Keio Univ, Sch Med, Shinjuku Ku, Tokyo, Japan

[4] Tokyo Univ Hosp, Bunkyo Ku, Tokyo 113, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 45期

关键词：

RESONANCE ENERGY-TRANSFER; TUMOR HYPOXIA; REDUCTION; CANCER; DESIGN; CELLS; PET;

D O I：

10.1021/ja105937q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Based on the findings that the azo functional group has excellent properties as the hypoxia-sensor moiety, we developed hypoxia-sensitive near-infrared fluorescent probes in which a large fluorescence increase is triggered by the cleavage of an azo bond. The probes were used for fluorescence imaging of hypoxic cells and real-time monitoring of ischemia in the liver and kidney of live mice.

引用

页码：15846 / 15848

页数：3

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