Targets of RNA-directed DNA methylation

被引：168

作者：

Matzke, Marjori ^{[1
]}

Kanno, Tatsuo ^{[1
]}

Huettel, Bruno ^{[1
]}

Daxinger, Lucia ^{[1
]}

Matzke, Antonius J. M. ^{[1
]}

机构：

[1] Austrian Acad Sci, Gregor Mendel Inst Mol Plant Biol, A-1030 Vienna, Austria

来源：

CURRENT OPINION IN PLANT BIOLOGY | 2007年 / 10卷 / 05期

基金：

奥地利科学基金会;

关键词：

D O I：

10.1016/j.pbi.2007.06.007

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

RNA-directed DNA methylation contributes substantially to epigenetic regulation of the plant genome. Methylation is guided to homologous DNA target sequences by 24 nt 'heterochromatic' small RNAs produced by nucleolar-localized components of the RNAi machinery and a plant-specific RNA polymerase, Pol IV. Plants contain unusually large and diverse populations of small RNAs, many of which originate from transposons and repeats. These sequences are frequent targets of methylation, and they are able to bring plant genes in their vicinity under small RNA-mediated control. RNA-directed DNA methylation can be removed by enzymatic demethylation, providing plants with a versatile system that facilitates epigenetic plasticity. In addition to subduing transposons, RNA-directed DNA methylation has roles in plant development and, perhaps, stress responses.

引用

页码：512 / 519

页数：8

共 69 条

[1] Role of the Arabidopsis DNA glycosylase/lyase ROS1 in active DNA demethylation
Agius, Fernanda
Kapoor, Avnish
Zhu, Jian-Kang
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (31) : 11796 - 11801
[2] An RNA-dependent RNA polymerase is required for paramutation in maize
Alleman, Mary
Sidorenko, Lyudmila
McGinnis, Karen
Seshadri, Vishwas
Dorweiler, Jane E.
White, Joshua
Sikkink, Kristin
Chandler, Vicki L.
[J]. NATURE, 2006, 442 (7100) : 295 - 298
[3] Developmentally regulated piRNA clusters implicate MILI in transposon control
Aravin, Alexei A.
Sachidanandam, Ravi
Girard, Angelique
Fejes-Toth, Katalin
Hannon, Gregory J.
[J]. SCIENCE, 2007, 316 (5825) : 744 - 747
[4] MicroRNA binding sites in Arabidopsis class IIIHD-ZIP mRNAs are required for methylation of the template chromosome
Bao, N
Lye, KW
Barton, MK
[J]. DEVELOPMENTAL CELL, 2004, 7 (05) : 653 - 662
[5] Arabidopsis ARGONAUTE1 is an RNA Slicer that selectively recruits rnicroRNAs and short interfering RNAs
Baumberger, N
Baulcombe, DC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (33) : 11928 - 11933
[6] Altered expression of the Arabidopsis ortholog of DCL affects normal plant development
Bellaoui, M
Gruissem, W
[J]. PLANTA, 2004, 219 (05) : 819 - 826
[7] Endogenous siRNAs derived from a pair of natural cis-antisense transcripts regulate salt tolerance in Arabidopsis
Borsani, O
Zhu, JH
Verslues, PE
Sunkar, R
Zhu, JK
[J]. CELL, 2005, 123 (07) : 1279 - 1291
[8] MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline
Carmell, Michelle A.
Girard, Angelique
van de Kant, Henk J. G.
Bourc'his, Deborah
Bestor, Timothy H.
de Rooij, Dirk G.
Hannon, Gregory J.
[J]. DEVELOPMENTAL CELL, 2007, 12 (04) : 503 - 514
[9] Two-step recruitment of RNA-directed DNA methylation to tandem repeats
Chan, Simon W. -L.
Zhang, Xiaoyu
Bernatavichute, Yana V.
Jacobsen, Steven E.
[J]. PLOS BIOLOGY, 2006, 4 (11) : 1923 - 1933
[10] RNAi, DRD1, and histone methylation actively target developmentally important non-CG DNA methylation in Arabidopsis
Chan, Simon W. -L.
Henderson, Ian R.
Zhang, Xiaoyu
Shah, Govind
Chien, Jason S. -C.
Jacobsen, Steven E.
[J]. PLOS GENETICS, 2006, 2 (06): : 791 - 797

← 1 2 3 4 5 6 7 →