Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data

被引：193

作者：

Doolan, DL

Southwood, S

Freilich, DA

Sidney, J

Graber, NL

Shatney, L

Bebris, L

Florens, L

Dobano, C

Witney, AA

Appella, E

Hoffman, SL

Yates, JR

Carucci, DJ

Sette, A ^{[1
]}

机构：

[1] Epimmune Inc, San Diego, CA 92121 USA

[2] USN, Med Res Ctr, Malaria Program, Silver Spring, MD 20910 USA

[3] Johns Hopkins Univ, Dept Mol Microbiol & Immunol, Sch Hyg & Publ Hlth, Baltimore, MD 21205 USA

[4] Henry M Jackson Fdn, Rockville, MD 20852 USA

[5] Scripps Res Inst, La Jolla, CA 92037 USA

[6] Torrey Mesa Res Inst, San Diego, CA 92121 USA

[7] NCI, Cell Biol Lab, NIH, Bethesda, MD 20892 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2003年 / 100卷 / 17期

关键词：

D O I：

10.1073/pnas.1633254100

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The recent explosion in genomic sequencing has made available a wealth of data that can now be analyzed to identify protein antigens, potential targets for vaccine development. Here we present, in the context of Plasmodium falciparum, a strategy that rapidly identifies target antigens from large and complex genomes. Sixteen antigenic proteins recognized by volunteers immunized with radiation-attenuated P. faiciparum sporozoites, but not by mock immunized controls, were identified. Several of these were more antigenic than previously identified and well characterized P. faiciparum-derived protein antigens. The data suggest that immune responses to Plasmodium are dispersed on a relatively large number of parasite antigens. These studies have implications for our understanding of immunodominance and breadth of responses to complex pathogens.

引用

页码：9952 / 9957

页数：6

共 39 条

[21] The genome sequence of the malaria mosquito Anopheles gambiae [J].

Holt, RA ;

Subramanian, GM ;

Halpern, A ;

Sutton, GG ;

Charlab, R ;

Nusskern, DR ;

Wincker, P ;

Clark, AG ;

Ribeiro, JMC ;

Wides, R ;

Salzberg, SL ;

Loftus, B ;

Yandell, M ;

Majoros, WH ;

Rusch, DB ;

Lai, ZW ;

Kraft, CL ;

Abril, JF ;

Anthouard, V ;

Arensburger, P ;

Atkinson, PW ;

Baden, H ;

de Berardinis, V ;

Baldwin, D ;

Benes, V ;

Biedler, J ;

Blass, C ;

Bolanos, R ;

Boscus, D ;

Barnstead, M ;

Cai, S ;

Center, A ;

Chatuverdi, K ;

Christophides, GK ;

Chrystal, MA ;

Clamp, M ;

Cravchik, A ;

Curwen, V ;

Dana, A ;

Delcher, A ;

Dew, I ;

Evans, CA ;

Flanigan, M ;

Grundschober-Freimoser, A ;

Friedli, L ;

Gu, ZP ;

Guan, P ;

Guigo, R ;

Hillenmeyer, ME ;

Hladun, SL .

SCIENCE, 2002, 298 (5591) :129-+

[22] PEPTIDES PRESENTED TO THE IMMUNE-SYSTEM BY THE MURINE CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE-I-A(D) [J].

HUNT, DF ;

MICHEL, H ;

DICKINSON, TA ;

SHABANOWITZ, J ;

COX, AL ;

SAKAGUCHI, K ;

APPELLA, E ;

GREY, HM ;

SETTE, A .

SCIENCE, 1992, 256 (5065) :1817-1820

[23]

Kawakami Y, 1997, Int Rev Immunol, V14, P173, DOI 10.3109/08830189709116851

[24] The multi-epitope approach for immunotherapy for cancer: Identification of several CTL epitopes from various tumor-associated antigens expressed on solid epithelial tumors [J].

Kawashima, I ;

Hudson, SJ ;

Tsai, V ;

Southwood, S ;

Takesako, K ;

Appella, E ;

Sette, A ;

Celis, E .

HUMAN IMMUNOLOGY, 1998, 59 (01) :1-14

[25] Cytomegalovirus (CMV) phosphoprotein 65 makes a large contribution to shaping the T cell repertoire in CMV-exposed individuals [J].

Kern, F ;

Bunde, T ;

Faulhaber, N ;

Kiecker, F ;

Khatamzas, E ;

Rudawski, IM ;

Pruss, A ;

Gratama, JW ;

Volkmer-Engert, R ;

Ewert, R ;

Reinke, P ;

Volk, HD ;

Picker, LJ .

JOURNAL OF INFECTIOUS DISEASES, 2002, 185 (12) :1709-1716

[26] Initial sequencing and analysis of the human genome [J].

Lander, ES ;

Int Human Genome Sequencing Consortium ;

Linton, LM ;

Birren, B ;

Nusbaum, C ;

Zody, MC ;

Baldwin, J ;

Devon, K ;

Dewar, K ;

Doyle, M ;

FitzHugh, W ;

Funke, R ;

Gage, D ;

Harris, K ;

Heaford, A ;

Howland, J ;

Kann, L ;

Lehoczky, J ;

LeVine, R ;

McEwan, P ;

McKernan, K ;

Meldrim, J ;

Mesirov, JP ;

Miranda, C ;

Morris, W ;

Naylor, J ;

Raymond, C ;

Rosetti, M ;

Santos, R ;

Sheridan, A ;

Sougnez, C ;

Stange-Thomann, N ;

Stojanovic, N ;

Subramanian, A ;

Wyman, D ;

Rogers, J ;

Sulston, J ;

Ainscough, R ;

Beck, S ;

Bentley, D ;

Burton, J ;

Clee, C ;

Carter, N ;

Coulson, A ;

Deadman, R ;

Deloukas, P ;

Dunham, A ;

Dunham, I ;

Durbin, R ;

French, L .

NATURE, 2001, 409 (6822) :860-921

[27] Progress and challenges for malaria vaccines [J].

Richie, TL ;

Saul, A .

NATURE, 2002, 415 (6872) :694-701

[28] ISOLATION AND ANALYSIS OF NATURALLY PROCESSED VIRAL PEPTIDES AS RECOGNIZED BY CYTOTOXIC T-CELLS [J].

ROTZSCHKE, O ;

FALK, K ;

DERES, K ;

SCHILD, H ;

NORDA, M ;

METZGER, J ;

JUNG, G ;

RAMMENSEE, HG .

NATURE, 1990, 348 (6298) :252-254

[29] PREDICTION OF MAJOR HISTOCOMPATIBILITY COMPLEX BINDING REGIONS OF PROTEIN ANTIGENS BY SEQUENCE PATTERN-ANALYSIS [J].

SETTE, A ;

BUUS, S ;

APPELLA, E ;

SMITH, JA ;

CHESNUT, R ;

MILES, C ;

COLON, SM ;

GREY, HM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (09) :3296-3300

[30] Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism [J].

Sette, A ;

Sidney, J .

IMMUNOGENETICS, 1999, 50 (3-4) :201-212

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