Pleiotropic actions of aldosterone and the effects of eplerenone, a selective mineralocorticoid receptor antagonist

被引：36

作者：

Takeda, Y ^{[1
]}

机构：

[1] Kanazawa Univ, Grad Sch Med Sci, Kanazawa, Ishikawa 9208641, Japan

来源：

HYPERTENSION RESEARCH | 2004年 / 27卷 / 11期

关键词：

aldosterone; hypertension; mineralocorticoid receptor; eplerenone; angiotensin II;

D O I：

10.1291/hypres.27.781

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Aldosterone plays an important role in the pathogenesis of cardiovascular and renal disease that is independent of angiotensin II. Mineralocorticoid receptors are expressed in nonepithelial tissues such as the heart and blood vessels. Although mineralocorticoid receptor antagonism reduces mortality in patients with congestive heart failure, the progestational and antiandrogenic side effects of the nonspecific mineralocorticold receptor antagonist, spironolactone, have limited its usefulness in the treatment of cardiovascular diseases. This review exmanines the expanding role of aldosterone, including its broad spectrum of non-classical effects, and the recent clinical and experimental trials with the selective mineralocorticoid receptor antagonist, eplerenone.

引用

页码：781 / 789

页数：9

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