Nitric oxide augments voltage-activated calcium currents of crustacea (Idotea baltica) skeletal muscle

被引：12

作者：

Erxleben, C

Hermann, A

机构：

[1] Salzburg Univ, Inst Zool, Dept Mol Neurobiol & Cellular Physiol, A-5020 Salzburg, Austria

[2] Staz Zool Anton Dohrn, Neurobiol Lab, I-80121 Naples, Italy

来源：

NEUROSCIENCE LETTERS | 2001年 / 300卷 / 03期

关键词：

calcium current; skeletal muscle; nitric oxide; Idotea baltica (crustacea; isopoda); invertebrate; voltage clamp;

D O I：

10.1016/S0304-3940(01)01571-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Invertebrate skeletal muscle contraction is regulated by calcium influx through voltage-dependent calcium channels in the sarcolemmal membrane. In present study we investigated the effects of nitric oxide (NO) donors on calcium currents of single skeletal muscle fibres from the marine isopod, Idotea baltica, using two-electrode voltage clamp recording techniques. The NO donors, S-nitrosocysteine, S-nitroso-N-acetyl-penicillamine or hydroxylamine reversibly increased calcium inward currents in a time dependent man ner. The increase of the current was prevented by methylene blue. Our experiments suggest that NO increases calcium inward currents. NO, by acting on calcium ion channels in the sarcolemmal membrane, therefore, may directly be involved in the modulation of muscle contraction. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：133 / 136

页数：4

共 31 条

[21] Effects of nitric oxide on the contraction of skeletal muscle [J].