Mitochondrial DNA analysis on remains of a putative son of Louis XVI, King of France and Marie-Antoinette

被引：27

作者：

Jehaes, E

Decorte, R

Peneau, A

Petrie, JH

Boiry, PA

Gilissen, A

Moisan, JP

Van den Berghe, H

Pascal, O

Cassiman, JJ

机构：

[1] Catholic Univ Louvain, Ctr Human Genet, B-3000 Louvain, Belgium

[2] CHRU, Mol Genet Lab, Nantes, France

[3] Petrus Campussingel, Groningen, Netherlands

[4] Fac Libre Sci Commun, Levallois Perret, France

来源：

EUROPEAN JOURNAL OF HUMAN GENETICS | 1998年 / 6卷 / 04期

关键词：

Louis XVII; mitochondrial DNA; ancient DNA; genetic identification;

D O I：

10.1038/sj.ejhg.5200227

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Carl Wilhelm Naundorff was buried in 1845 in Delft as Louis Charles, Duc de Normandie, 'Louis XVII', However, the son of Louis XVI and Marie-Antoinette - Louis XVII - officially died in the Temple of Paris in 1795, In order to resolve the identity of Naundorff, mitochondrial DNA (mtDNA) D-loop sequences of his remains were compared with the sequences obtained from the hairs of two sisters of Marie-Antoinette, Marie-Antoinette herself, and with the sequences obtained from DNA samples of two living maternal relatives, The mtDNA sequence of a bone sample from Naundorff showed two nucleotide differences from the sequences of the three sisters and four differences from the sequences of living maternal relatives. Based on this evidence it becomes very unlikely that Naundorff is the son of Marie-Antoinette.

引用

页码：383 / 395

页数：13

共 33 条

[1] SEQUENCE AND ORGANIZATION OF THE HUMAN MITOCHONDRIAL GENOME [J].

ANDERSON, S ;

BANKIER, AT ;

BARRELL, BG ;

DEBRUIJN, MHL ;

COULSON, AR ;

DROUIN, J ;

EPERON, IC ;

NIERLICH, DP ;

ROE, BA ;

SANGER, F ;

SCHREIER, PH ;

SMITH, AJH ;

STADEN, R ;

YOUNG, IG .

NATURE, 1981, 290 (5806) :457-465

[2]

AQUADRO CF, 1983, GENETICS, V103, P287

[3] The impact of population expansion and mutation rate heterogeneity on DNA sequence polymorphism [J].

ArisBrosou, S ;

Excoffier, L .

MOLECULAR BIOLOGY AND EVOLUTION, 1996, 13 (03) :494-504

[4]

BALLINGER SW, 1992, GENETICS, V130, P139

[5]

BOGENHAGEN D, 1974, J BIOL CHEM, V249, P7991

[6]

CHEN YS, 1995, AM J HUM GENET, V57, P133

[7] Evaluation of the ALF DNA sequencer for high-speed sizing of short tandem repeat alleles [J].

Decorte, R ;

Cassiman, JJ .

ELECTROPHORESIS, 1996, 17 (10) :1542-1549

[8]

Decorte R, 1996, ADV FOREN H, V6, P17

[9]

Eckert K A, 1991, PCR Methods Appl, V1, P17

[10] IDENTIFICATION OF THE REMAINS OF THE ROMANOV FAMILY BY DNA ANALYSIS [J].

GILL, P ;

IVANOV, PL ;

KIMPTON, C ;

PIERCY, R ;

BENSON, N ;

TULLY, G ;

EVETT, I ;

HAGELBERG, E ;

SULLIVAN, K .

NATURE GENETICS, 1994, 6 (02) :130-135

← 1 2 3 4 →