Construction of combinatorial chemical libraries using a rapid and efficient solid phase synthesis based on a multicomponent condensation reaction

被引：25

作者：

Kim, SW ^{[1
]}

Bauer, SM ^{[1
]}

Armstrong, RW ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Biochem & Chem, Los Angeles, CA 90095 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 39期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(98)01547-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A 96 member library of acylated dipeptides based on a known anticonvulsant was synthesized utilizing an Ugi four component condensation followed by derivitization through nucleophilic displacement of a Weinreb type amide. The library afforded compounds in reasonable yield and high purity after cleavage from solid support. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：6993 / 6996

页数：4

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