Adeno-associated virus expression systems for gene transfer

被引：115

作者：

Rabinowitz, JE ^{[1
]}

Samulski, J ^{[1
]}

机构：

[1] Univ N Carolina, Human Gene Therapy Ctr, Chapel Hill, NC 27599 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1998年 / 9卷 / 05期

关键词：

D O I：

10.1016/S0958-1669(98)80031-1

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In contrast to other gene delivery systems, adeno-associated virus vectors show long term gene expression without immune response or toxicity. New production methods have increased vector titers and eliminated adenovirus contamination, thereby facilitating effective in vivo use. These advancements will expedite additional animal model studies providing validation for use of this vector in human clinical trials.

引用

页码：470 / 475

页数：6