Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes

被引：405

作者：

Jope, RS ^{[1
]}

机构：

[1] Univ Alabama, Dept Psychiat & Behav Neurobiol, Sparks Ctr 1057, Birmingham, AL 35294 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2003年 / 24卷 / 09期

关键词：

D O I：

10.1016/S0165-6147(03)00206-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The intrigue of lithium, the simplest drug in the modern pharmacopoeia, extends from its complex actions in cells to its therapeutic effects as a mood stabilizer. New surprises from studies of glycogen synthase kinase 3 (GSK-3) show that lithium reduces GSK-3 activity in two ways, both directly and by increasing the inhibitory phosphorylation of GSK-3. These dual effects can act in concert to magnify the influence of lithium on crucial GSK-3-regulated functions (gene expression, cell structure and survival).

引用

页码：441 / 443

页数：3

共 26 条

[1] Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3β [J].

Beffert, U ;

Morfini, G ;

Bock, HH ;

Reyna, H ;

Brady, ST ;

Herz, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (51) :49958-49964

[2] Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons [J].

Chalecka-Franaszek, E ;

Chuang, DM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (15) :8745-8750

[3] Neuroprotective effects of lithium in cultured cells and animal models of diseases [J].

Chuang, DM ;

Chen, RW ;

Chalecka-Franaszek, E ;

Ren, M ;

Hashimoto, R ;

Senatorov, V ;

Kanai, H ;

Hough, C ;

Hiroi, T ;

Leeds, P .

BIPOLAR DISORDERS, 2002, 4 (02) :129-136

[4] The renaissance of GSK3 [J].

Cohen, P ;

Frame, S .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2001, 2 (10) :769-776

[5] Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death [J].

Cross, DAE ;

Culbert, AA ;

Chalmers, KA ;

Facci, L ;

Skaper, SD ;

Reith, AD .

JOURNAL OF NEUROCHEMISTRY, 2001, 77 (01) :94-102

[6] Regulation of Akt and glycogen synthase kinase-3β phosphorylation by sodium valproate and lithium [J].

De Sarno, P ;

Li, XH ;

Jope, RS .

NEUROPHARMACOLOGY, 2002, 43 (07) :1158-1164

[7] An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Sernaphorin 3A signaling [J].

Eickholt, BJ ;

Walsh, FS ;

Doherty, P .

JOURNAL OF CELL BIOLOGY, 2002, 157 (02) :211-217

[8] Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity [J].

Etienne-Manneville, S ;

Hall, A .

NATURE, 2003, 421 (6924) :753-756

[9] Lithium ameliorates HIV-gp120-mediated neurotoxicity [J].

Everall, IP ;

Bell, C ;

Mallory, M ;

Langford, D ;

Adame, A ;

Rockestein, E ;

Masliah, E .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2002, 21 (03) :493-501

[10] The multifaceted roles of glycogen synthase kinase 3β in cellular signaling [J].

Grimes, CA ;

Jope, RS .

PROGRESS IN NEUROBIOLOGY, 2001, 65 (04) :391-426

← 1 2 3 →