Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes

被引：405

作者：

Jope, RS ^{[1
]}

机构：

[1] Univ Alabama, Dept Psychiat & Behav Neurobiol, Sparks Ctr 1057, Birmingham, AL 35294 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2003年 / 24卷 / 09期

关键词：

D O I：

10.1016/S0165-6147(03)00206-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The intrigue of lithium, the simplest drug in the modern pharmacopoeia, extends from its complex actions in cells to its therapeutic effects as a mood stabilizer. New surprises from studies of glycogen synthase kinase 3 (GSK-3) show that lithium reduces GSK-3 activity in two ways, both directly and by increasing the inhibitory phosphorylation of GSK-3. These dual effects can act in concert to magnify the influence of lithium on crucial GSK-3-regulated functions (gene expression, cell structure and survival).

引用

页码：441 / 443

页数：3

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