Modeling the active site chemistry of liver alcohol dehydrogenase:: Mononuclear zinc methanol and N,N-Dimethylformamide complexes of a nitrogen/sulfur ligand possessing an internal hydrogen bond donor

被引：49

作者：

Berreau, LM ^{[1
]}

Makowska-Grzyska, MM

Arif, AM

机构：

[1] Univ Utah, Dept Biochem & Chem, Salt Lake City, UT 84322 USA

[2] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA

来源：

INORGANIC CHEMISTRY | 2001年 / 40卷 / 10期

关键词：

D O I：

10.1021/ic001190h

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Using a novel nitrogen/sulfur ligand possessing a single internal hydrogen bond donor (bmapa, N,N-bis-(2-methylthio)ethyl-N-(6-amino-2-pyridylmethyl)- amine), mononuclear zinc complexes possessing a single zinc-bound methanol ([(bmapa)Zn(MeOH)]-(ClO4)(2) . MeOH, 1 . MeOH) or N,N-dimethylformamide ([(bmapa)Zn(DMF)](ClO4)(2), 2) molecule have been synthesized and structurally characterized. These complexes are structurally relevant to substrate- and inhibitor-bound forms of liver alcohol dehydrogenase (LADH) and exhibit hydrogen-bonding interactions akin to those found in the active site of LADH.

引用

页码：2212 / +

页数：3

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