Modeling the catalytic cycle of liver alcohol dehydrogenase:: Synthesis and structural characterization of a four-coordinate zinc ethoxide complex and determination of relative Zn-OR versus Zn-OH bond energies

被引：70

作者：

Bergquist, C ^{[1
]}

Parkin, G ^{[1
]}

机构：

[1] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

INORGANIC CHEMISTRY | 1999年 / 38卷 / 03期

关键词：

D O I：

10.1021/ic981267q

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Relative Zn-OR (R = H, Me, Et, Bu-t) heterolytic bond energies, of relevance to the catalytic cycle of liver alcohol dehydrogenase (LADH), have been determined by studying a series of alkoxide exchange equilibria. The alkoxides [Tp(But,Me)]ZnOR also undergo "hydride" transfer reactions which are related to the mechanism of action of LADH.

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页码：422 / +

页数：3

相关论文

共 24 条

[1] AN L(3)ZNOH COMPLEX AS A FUNCTIONAL-MODEL OF THE ENZYME CARBONIC-ANHYDRASE [J].

ALSFASSER, R ;

RUF, M ;

TROFIMENKO, S ;

VAHRENKAMP, H .

CHEMISCHE BERICHTE-RECUEIL, 1993, 126 (03) :703-710

[2] A MONONUCLEAR ZINC HYDROXIDE COMPLEX STABILIZED BY A HIGHLY SUBSTITUTED TRIS(PYRAZOLY)HYDROBORATO LIGAND - ANALOGIES WITH THE ENZYME CARBONIC-ANHYDRASE [J].

ALSFASSER, R ;

TROFIMENKO, S ;

LOONEY, A ;

PARKIN, G ;

VAHRENKAMP, H .

INORGANIC CHEMISTRY, 1991, 30 (21) :4098-4100

[3] MONOMERIC METAL-HYDROXIDES, ALKOXIDES, AND AMIDES OF THE LATE TRANSITION-METALS - SYNTHESIS, REACTIONS, AND THERMOCHEMISTRY [J].

BRYNDZA, HE ;

TAM, W .

CHEMICAL REVIEWS, 1988, 88 (07) :1163-1188

[4]

Burth R, 1998, Z ANORG ALLG CHEM, V624, P381, DOI 10.1002/(SICI)1521-3749(199803)624:3<381::AID-ZAAC381>3.3.CO

[5]

2-Y

[6]

COLEMAN JE, 1986, PROGR INORGANIC BIOC, V1, pCH4

[7] Elaboration of the bis(pyrazolyl)hydroborato ligand [Bp(Bu-t,Pr-i)] into the NNO donor ligand, [(MeO)Bp(Bu-t,Pr-i)]: Structural characterization of a complex in which the [(MeO)Bp(Bu-t,Pr-i)] ligand models the binding of zinc to the peptide backbone in thermolysin [J].

Dowling, C ;

Parkin, G .

POLYHEDRON, 1996, 15 (14) :2463-2465

[8] A COMPREHENSIVE ENERGY COMPONENT ANALYSIS OF THE INTERACTION OF HARD AND SOFT DICATIONS WITH BIOLOGICAL LIGANDS [J].

GARMER, DR ;

GRESH, N .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (08) :3556-3567

[9] Modeling the active sites of bacteriophage T7 lysozyme, bovine 5-aminolevulinate dehydratase, and peptide deformylase:: synthesis and structural characterization of a bis(pyrazolyl)(thioalkoxy)hydroborato zinc complex, [(Ph2CHS)BpBu-t,Pr-i]ZnI [J].

Ghosh, P ;

Parkin, G .

CHEMICAL COMMUNICATIONS, 1998, (03) :413-414

[10] ENERGETICS OF ZN2+ BINDING TO A SERIES OF BIOLOGICALLY RELEVANT LIGANDS - A MOLECULAR MECHANICS INVESTIGATION GROUNDED ON AB-INITIO SELF-CONSISTENT-FIELD SUPERMOLECULAR COMPUTATIONS [J].

GRESH, N .

JOURNAL OF COMPUTATIONAL CHEMISTRY, 1995, 16 (07) :856-882