CDC6:: from DNA replication to cell cycle checkpoints and oncogenesis

被引：196

作者：

Borlado, Luis R. ^{[1
]}

Mendez, Juan ^{[1
]}

机构：

[1] Spanish Natl Canc Res Ctr, DNA Replicat Grp, Mol Oncol Programme, E-28029 Madrid, Spain

来源：

CARCINOGENESIS | 2008年 / 29卷 / 02期

关键词：

D O I：

10.1093/carcin/bgm268

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cell division cycle 6 (CDC6) is an essential regulator of DNA replication in eukaryotic cells. Its best-characterized function is the assembly of prereplicative complexes at origins of replication during the G(1) phase of the cell division cycle. However, CDC6 also plays important roles in the activation and maintenance of the checkpoint mechanisms that coordinate S phase and mitosis, and recent studies have unveiled its proto-oncogenic activity. CDC6 overexpression interferes with the expression of INK4/ARF tumor suppressor genes through a mechanism involving the epigenetic modification of chromatin at the INK4/ARF locus. In addition, CDC6 overexpression in primary cells may promote DNA hyperreplication and induce a senescence response similar to that caused by oncogene activation. These findings indicate that deregulation of CDC6 expression in human cells poses a serious risk of carcinogenesis.

引用

页码：237 / 243

页数：7

共 104 条

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