STroke imAging pRevention and treatment (START): A longitudinal stroke cohort study: Clinical trials protocol

被引：27

作者：

Carey, Leeanne M. ^{[1
,2
]}

Crewther, Sheila ^{[1
,3
]}

Salvado, Olivier ^{[4
]}

Linden, Thomas ^{[1
,5
]}

Connelly, Alan ^{[6
]}

Wilson, William ^{[7
]}

Howells, David W. ^{[1
]}

Churilov, Leonid ^{[1
]}

Ma, Henry ^{[1
,8
]}

Tse, Tamara ^{[1
,2
]}

Rose, Stephen ^{[4
]}

Palmer, Susan ^{[1
]}

Bougeat, Pierrick ^{[4
]}

Campbell, Bruce C. V. ^{[9
]}

Christensen, Soren ^{[9
]}

Macaulay, S. Lance ^{[10
]}

Favaloro, Jenny ^{[1
]}

O' Collins, Victoria ^{[1
]}

McBride, Simon ^{[4
]}

Bates, Susan ^{[11
]}

Cowley, Elise ^{[11
]}

Dewey, Helen ^{[12
]}

Wijeratne, Tissa ^{[13
]}

Gerraty, Richard ^{[14
]}

Phan, Thanh G. ^{[8
]}

Yan, Bernard ^{[9
]}

Parsons, Mark W. ^{[15
]}

Bladin, Chris ^{[16
]}

Barber, P. Alan ^{[17
]}

Read, Stephen ^{[18
]}

Wong, Andrew ^{[18
]}

Lee, Andrew ^{[19
]}

Kleinig, Tim ^{[20
]}

Hankey, Graeme J. ^{[21
,22
]}

Blacker, David ^{[22
]}

Markus, Romesh ^{[23
]}

Leyden, James ^{[24
]}

Krause, Martin ^{[25
]}

Grimley, Rohan ^{[26
]}

Mahant, Neil ^{[27
]}

Jannes, Jim ^{[28
]}

Sturm, Jonathan ^{[29
]}

Davis, Stephen M. ^{[9
]}

Donnan, Geoffrey A. ^{[1
]}

机构：

[1] Natl Stroke Res Inst, Florey Inst Neurosci & Mental Hlth, Heidelberg, Vic 3084, Australia

[2] La Trobe Univ, Dept Occupat Therapy, Sch Allied Hlth, Bundoora, Vic, Australia

[3] La Trobe Univ, Sch Psychol Sci, Bundoora, Vic, Australia

[4] Australian E Hlth Res Ctr, Preventat Hlth Natl Res Flagship, CSIRO, Herston, Qld, Australia

[5] Gothenburg Univ, Inst Neurosci & Physiol, Sahlgrenska Acad, Gothenburg, Sweden

[6] Florey Inst Neurosci & Mental Hlth, Brain Res Inst, Heidelberg, Vic, Australia

[7] Preventat Hlth Natl Res Flagship, Neurodegenerat Dis Mental Disorders & Brain Hlth, CSIRO, N Ryde, NSW, Australia

[8] Monash Univ, Stroke Unit, Monash Med Ctr, Dept Med, Clayton, Vic, Australia

[9] Univ Melbourne, Royal Melbourne Hosp, Dept Med, Melbourne Brain Ctr, Parkville, Vic, Australia

[10] Preventat Hlth Natl Res Flagship, Neurodegenerat Dis Mental Disorders & Brain Hlth, CSIRO, Parkville, Vic, Australia

[11] Melbourne Brain Ctr, Neurosci Trials Australia, Heidelberg, Vic, Australia

[12] Austin Hlth, Dept Neurol, Heidelberg, Vic, Australia

[13] Western Hosp, Dept Neurol, Western Hlth, Melbourne, Vic, Australia

[14] Epworth Healthcare, Melbourne, Vic, Australia

[15] Univ Newcastle, John Hunter Hosp, Dept Neurol, Newcastle, NSW 2300, Australia

[16] Box Hill Hosp, Dept Neurol, Eastern Hlth, Melbourne, Vic, Australia

[17] Auckland City Hosp, Dept Neurol, Auckland, New Zealand

[18] Royal Brisbane & Womens Hosp, Dept Neurol, Brisbane, Qld, Australia

[19] Flinders Med Ctr & Univ, Flinders Comprehens Stroke Ctr, Adelaide, SA, Australia

[20] Royal Adelaide Hosp, Dept Neurol, Adelaide, SA 5000, Australia

[21] Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6009, Australia

[22] Sir Charles Gairdner Hosp, Dept Neurol, Perth, WA, Australia

[23] St Vincents Hosp, Dept Neurol, Sydney, NSW 2010, Australia

[24] Lyell McEwin Hosp, Dept Neurol, Adelaide, SA, Australia

[25] Royal N Shore Hosp, Dept Neurol, Sydney, NSW, Australia

[26] Nambour Gen Hosp, Dept Neurol, Nambour, Qld, Australia

[27] Westmead Hosp, Dept Neurol, Sydney, NSW, Australia

[28] Queen Elizabeth Hosp, Dept Neurol, Adelaide, SA, Australia

[29] Gosford Hosp, Dept Neurol, Gosford, NSW, Australia

来源：

INTERNATIONAL JOURNAL OF STROKE | 2015年 / 10卷 / 04期

基金：

澳大利亚研究理事会;

关键词：

cohort; cortical thickness; depression; functional neuroimaging; gene expression; stroke; POSTSTROKE DEPRESSION; VALIDATION; PARTICIPATION; INFLAMMATION; RELIABILITY; SYMPTOMS; MARKERS; SCALE; STATE; TOOL;

D O I：

10.1111/ijs.12190

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

RationaleStroke and poststroke depression are common and have a profound and ongoing impact on an individual's quality of life. However, reliable biological correlates of poststroke depression and functional outcome have not been well established in humans. AimsOur aim is to identify biological factors, molecular and imaging, associated with poststroke depression and recovery that may be used to guide more targeted interventions. DesignIn a longitudinal cohort study of 200 stroke survivors, the START - STroke imAging pRevention and Treatment cohort, we will examine the relationship between gene expression, regulator proteins, depression, and functional outcome. Stroke survivors will be investigated at baseline, 24h, three-days, three-months, and 12 months poststroke for blood-based biological associates and at days 3-7, three-months, and 12 months for depression and functional outcomes. A sub-group (n=100), the PrePARE: Prediction and Prevention to Achieve optimal Recovery Endpoints after stroke cohort, will also be investigated for functional and structural changes in putative depression-related brain networks and for additional cognition and activity participation outcomes. Stroke severity, diet, and lifestyle factors that may influence depression will be monitored. The impact of depression on stroke outcomes and participation in previous life activities will be quantified. Study OutcomesClinical significance lies in the identification of biological factors associated with functional outcome to guide prevention and inform personalized and targeted treatments. Evidence of associations between depression, gene expression and regulator proteins, functional and structural brain changes, lifestyle and functional outcome will provide new insights for mechanism-based models of poststroke depression.

引用

页码：636 / 644

页数：9

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