Tolerance-induced receptor selection:: scope, sensitivity, locus specificity, and relationship to lymphocyte-positive selection

被引:17
作者
Aït-Azzouzene, D
Skog, P
Retter, M
Kouskoff, V
Hertz, M
Lang, J
Kench, J
Chumley, M
Melamed, D
Sudaria, J
Gavin, A
Martensson, A
Verkoczy, L
Duong, B
Vela, J
Nemazee, D
机构
[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA
[2] Natl Jewish Med & Res Ctr, Denver, CO USA
[3] Scripps Res Inst, Doctoral Program Chem & Biol Sci, La Jolla, CA USA
关键词
D O I
10.1111/j.0105-2896.2004.0106.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Receptor editing is a mode of immunological tolerance of B lymphocytes that involves antigen-induced B-cell receptor signaling and consequent secondary immunoglobulin light chain gene recombination. This ongoing rearrangement often changes B-cell specificity for antigen, rendering the cell non-autoreactive and sparing it from deletion. We currently believe that tolerance-induced editing is limited to early stages in B-cell development and that it is a major mechanism of tolerance, with a low-affinity threshold and the potential to take place in virtually every developing B cell. The present review highlights the contributions from our laboratory over several years to elucidate these features.
引用
收藏
页码:219 / 230
页数:12
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