Genotyping errors: Causes, consequences and solutions

被引：920

作者：

Pompanon, F ^{[1
]}

Bonin, A ^{[1
]}

Bellemain, E ^{[1
]}

Taberlet, P ^{[1
]}

机构：

[1] Univ Grenoble 1, CNRS, UMR 5553, Lab Ecol Alpine, F-38041 Grenoble, France

来源：

NATURE REVIEWS GENETICS | 2005年 / 6卷 / 11期

关键词：

D O I：

10.1038/nrg1707

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Although genotyping errors affect most data and can markedly influence the biological conclusions of a study, they are too often neglected. Errors have various causes, but their occurrence and effect can be limited by considering these causes in the production and analysis of the data. Procedures that have been developed for dealing with errors in linkage studies, forensic analyses and non-invasive genotyping should be applied more broadly to any genetic study. We propose a protocol for estimating error rates and recommend that these measures be systemically reported to attest the reliability of published genotyping studies.

引用

页码：847 / 859

页数：13

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