Progress in the noninvasive, in-vivo, tissue modulated Raman spectroscopy of human blood

被引:14
作者
Chaiken, J [1 ]
Finney, WF [1 ]
Yang, XK [1 ]
Knudson, PE [1 ]
Peterson, KP [1 ]
Peterson, CM [1 ]
Weinstock, RS [1 ]
Hagrman, D [1 ]
机构
[1] Syracuse Univ, Ctr Sci & Technol 1 014, Dept Chem, Syracuse, NY 13244 USA
来源
BIOMEDICAL DIAGNOSTIC, GUIDANCE, AND SURGICAL-ASSIST SYSTEMS III | 2001年 / 4254卷
关键词
noninvasive; in vivo Raman spectroscopy; Blood Analysis; microcirculation;
D O I
10.1117/12.427936
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
We have recently presented the first Raman spectra of in vivo human blood. A brief review of how to obtain such spectra and normalize them to the appropriate blood volume is given showing how to produce spectra that can be used for noninvasive quantitative analysis of blood in vivo. New clinical data from individuals and groups completely reproduce and extend all the earlier results. These new data reveal how certain small differences between individuals result in some variability in their noninvasive quantitation. We show the origin of this variability and how to obtain quantitative corrections based entirely on the individual measurement and tabulated data.
引用
收藏
页码:216 / 227
页数:12
相关论文
共 24 条
[1]   THE OPTICS OF HUMAN-SKIN [J].
ANDERSON, RR ;
PARRISH, JA .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1981, 77 (01) :13-19
[2]   Phantom glucose calibration models from simulated noninvasive human near-infrared spectra [J].
Arnold, MA ;
Burmeister, JJ ;
Small, GW .
ANALYTICAL CHEMISTRY, 1998, 70 (09) :1773-1781
[3]   AXIAL TRANSMISSIVE F/1.8 IMAGING RAMAN SPECTROGRAPH WITH VOLUME-PHASE HOLOGRAPHIC FILTER AND GRATING [J].
BATTEY, DE ;
SLATER, JB ;
WLUDYKA, R ;
OWEN, H ;
PALLISTER, DM ;
MORRIS, MD .
APPLIED SPECTROSCOPY, 1993, 47 (11) :1913-1919
[4]  
Beebe K.R., 1998, CHEMOMETRICS PRACTIC
[5]   Multicomponent blood analysis by near-infrared Raman spectroscopy [J].
Berger, AJ ;
Koo, TW ;
Itzkan, I ;
Horowitz, G ;
Feld, MS .
APPLIED OPTICS, 1999, 38 (13) :2916-2926
[6]   Rapid, noninvasive concentration measurements of aqueous biological analytes by near-infrared Raman spectroscopy [J].
Berger, AJ ;
Wang, Y ;
Feld, MS .
APPLIED OPTICS, 1996, 35 (01) :209-212
[7]  
Burmeister J J, 2000, Diabetes Technol Ther, V2, P5, DOI 10.1089/152091500316683
[8]   In vivo determination of the molecular composition of artery wall by intravascular Raman spectroscopy [J].
Buschman, HP ;
Marple, ET ;
Wach, ML ;
Bennett, B ;
Schut, TCB ;
Bruining, HA ;
Bruschke, AV ;
van der Laarse, A ;
Puppels, GJ .
ANALYTICAL CHEMISTRY, 2000, 72 (16) :3771-3775
[9]   Noninvasive, in-vivo, near infrared vibrational spectroscopic study of lipid and aqueous phases of skin and near surface tissues [J].
Chaiken, J ;
Finney, WF ;
Peterson, K ;
Peterson, C ;
Knudson, PE ;
Weinstock, RS ;
Lein, P .
LASERS IN SURGERY: ADVANCED CHARACTERIZATION, THERAPEUTICS, AND SYSTEMS X, 2000, 3907 :89-97
[10]   Noninvasive, in vivo, tissue modulated near infrared vibrational spectroscopic study of mobile and static tissues: blood chemistry [J].
Chaiken, J ;
Finney, WF ;
Peterson, CM ;
Peterson, KP ;
Knudson, PE ;
Weinstock, RS ;
Lein, P .
BIOMEDICAL SPECTROSCOPY: VIBRATIONAL SPECTROSCOPY AND OTHER NOVEL TECHNIQUES, 2000, 3918 :135-143