Total synthesis of (-)-scabronine G, an inducer of neurotrophic factor production

被引：89

作者：

Waters, SP

Tian, Y

Li, YM

Danishefsky, SJ

机构：

[1] Sloan Kettering Inst Canc REs, Lab Bioorgan Chem, New York, NY 10021 USA

[2] Sloan Kettering Inst Canc Res, Lab Biochem &n Pharamcol, New York, NY 10021 USA

[3] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 39期

关键词：

D O I：

10.1021/ja055220x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The total synthesis of (-)-scabronine G has been achieved in a concise manner from the (-)-Wieland-Miescher ketone. Scabronine G and its more potent methyl ester (also prepared) display activity as nonpeptidyl inducers of nerve growth factor production. Copyright © 2005 American Chemical Society.

引用

页码：13514 / 13515

页数：2

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