Control of segment number in vertebrate embryos

被引：328

作者：

Gomez, Celine ^{[1
]}

Ozbudak, Ertugrul M. ^{[1
]}

Wunderlich, Joshua ^{[1
]}

Baumann, Diana ^{[1
]}

Lewis, Julian ^{[2
]}

Pourquie, Olivier ^{[1
,3
]}

机构：

[1] Stowers Inst Med Res, Kansas City, MO 64110 USA

[2] London Res Inst, Canc Res UK, Vertebrate Dev Lab, London WC2A 3PX, England

[3] Howard Hughes Med Inst, Kansas City, MO 64110 USA

来源：

NATURE | 2008年 / 454卷 / 7202期

关键词：

D O I：

10.1038/nature07020

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The vertebrate body axis is subdivided into repeated segments, best exemplified by the vertebrae that derive from embryonic somites. The number of somites is precisely defined for any given species but varies widely from one species to another. To determine the mechanism controlling somite number, we have compared somitogenesis in zebrafish, chicken, mouse and corn snake embryos. Here we present evidence that in all of these species a similar 'clock-and-wavefront'(1-3) mechanism operates to control somitogenesis; in all of them, somitogenesis is brought to an end through a process in which the presomitic mesoderm, having first increased in size, gradually shrinks until it is exhausted, terminating somite formation. In snake embryos, however, the segmentation clock rate is much faster relative to developmental rate than in other amniotes, leading to a greatly increased number of smaller-sized somites.

引用

页码：335 / 339

页数：5

共 31 条

[1] Wnt3A plays a major role in the segmentation clock controlling somitogenesis [J].