Apoptosis pathways in neuroblastoma therapy

被引:43
作者
Fulda, S [1 ]
Debatin, KM [1 ]
机构
[1] Univ Ulm, Childrens Hosp, D-89075 Ulm, Germany
关键词
neuroblastoma; apoptosis; caspases; mitochondria; death receptors; chemotherapy; cytotoxic; targeting; CD95; APO-1; FAS; TRAIL; therapy; drug response; chemoresistance; p53;
D O I
10.1016/S0304-3835(03)00091-0
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Apoptosis, the cell's intrinsic death program, plays a crucial role in the regulation of tissue homeostasis, and an imbalance between cell death and proliferation may result in tumor formation. Also, killing of tumor cells by diverse cytotoxic approaches such as anticancer drugs, gamma-irradiation, suicide genes or immunotherapy, is predominantly mediated through induction of apoptosis. Failure to activate apoptotic pathways in response to drug treatment may lead to resistance of neuroblastoma cells to anticancer therapies. Understanding the molecular events that regulate apoptosis induced by cytotoxic therapies and how neuroblastoma cells evade apoptotic events may provide a new paradigm for neuroblastoma therapy. Thus, novel strategies targeting resistance of neuroblastoma cells will be based on insights into the molecular mechanisms of apoptosis as well as other forms of cell death. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:131 / 135
页数:5
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