Direct catalytic asymmetric aldol reactions promoted by a novel barium complex

被引：102

作者：

Yamada, YMA ^{[1
]}

Shibasaki, M ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 31期

关键词：

aldol reactions; asymmetric catalysis; barium and compounds; unmodified ketones;

D O I：

10.1016/S0040-4039(98)01120-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A direct catalytic asymmetric aldol reaction of an aldehyde and an unmodified ketone promoted by an asymmetric barium complex has been achieved. The possible structure of the barium catalyst, BaB-M, which possesses the function of a Lewis acid and a Bronsted base, was characterized by LDI-TOFMS, C-13-NMR spectroscopy and extensive studies of reaction conditions. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：5561 / 5564

页数：4

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