Microwave-promoted reactions: Intramolecular carbanilide cyclization to hydantoins employing barium hydroxide catalyst.

被引：15

作者：

Gong, YD ^{[1
]}

Kurth, MJ ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 21期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(98)00497-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hydantoin ring formation via carbanilide cyclization is achieved in high yield with short reaction time by employing catalytic amounts of Ba(OH)(2) (anhydrous or octahydrate) in DMF under microwave irradiation. Evidence is provided that kinetic product 4 (trans, anti, cis stereochemistry) epimerizes to thermodynamic product 3 (trans, anti, trans stereochemistry). (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：3379 / 3382

页数：4

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