Solution phase library of perhydrooxazin-4-ones.

被引：18

作者：

Panunzio, M

Villa, M

Missio, A

Rossi, T

Seneci, P

机构：

[1] CNR, CSFM, Dipartimento Chim G Ciamician, I-40126 Bologna, Italy

[2] Glaxo Wellcome, Med Res Ctr, I-37135 Verona, Italy

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 36期

关键词：

Diels-Alder reactions; combinatorial chemistry; oxazines; azadienes; silylimines;

D O I：

10.1016/S0040-4039(98)01372-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general approach to the solution phase parallel synthesis of perhydrooxazin-4-ones, which allows the preparation of milligram quantities of each individual member, is reported. An efficient purification; method, using as "Sequestration Enabling Reagent" (SER) aminomethylpolystyrene resin in the presence of trimethylorthoformate is also described. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：6585 / 6588

页数：4

相关论文

共 15 条

[1] The preparation and first application of a polymer-supported ''Evans'' oxazolidinone. [J].

Allin, SM ;

Shuttleworth, SJ .

TETRAHEDRON LETTERS, 1996, 37 (44) :8023-8026

[2]

Bandini E, 1996, SYNLETT, P1017

[3] Trans-diastereoselective synthesis of 3-phthalimido beta-lactams via a two step-Staudinger reaction. [J].

Bandini, E ;

Martelli, G ;

Spunta, G ;

Bongini, A ;

Panunzio, M .

TETRAHEDRON LETTERS, 1996, 37 (25) :4409-4412

[4]

BANDINI E, UNPUB

[5] Hetero Diels-Alder vs electrocyclic reaction of azadiene: Selective synthesis of all stereoisomers of threonines [J].

Bongini, A ;

Panunzio, M ;

Bandini, E ;

Martelli, G ;

Spunta, G .

JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (25) :8911-8913

[6] APPLICATIONS OF COMBINATORIAL TECHNOLOGIES TO DRUG DISCOVERY .1. BACKGROUND AND PEPTIDE COMBINATORIAL LIBRARIES [J].

GALLOP, MA ;

BARRETT, RW ;

DOWER, WJ ;

FODOR, SPA ;

GORDON, EM .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (09) :1233-1251

[7] APPLICATIONS OF COMBINATORIAL TECHNOLOGIES TO DRUG DISCOVERY .2. COMBINATORIAL ORGANIC-SYNTHESIS, LIBRARY SCREENING STRATEGIES, AND FUTURE-DIRECTIONS [J].

GORDON, EM ;

BARRETT, RW ;

DOWER, WJ ;

FODOR, SPA ;

GALLOP, MA .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (10) :1385-1401

[8] TAGGED VERSUS UNTAGGED LIBRARIES - METHODS FOR THE GENERATION AND SCREENING OF COMBINATORIAL CHEMICAL LIBRARIES [J].

JANDA, KD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (23) :10779-10785

[9] Synthesis and use of N-(trimethylsilyl)imines [J].

Panunzio, M ;

Zarantonello, P .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 1998, 2 (01) :49-59

[10] In situ chemical tagging: Tetrafluorophthalic anhydride as a ''sequestration enabling reagent'' (SER) in the purification of solution-phase combinatorial libraries [J].

Parlow, JJ ;

Naing, W ;

South, MS ;

Flynn, DL .

TETRAHEDRON LETTERS, 1997, 38 (46) :7959-7962