In situ chemical tagging: Tetrafluorophthalic anhydride as a ''sequestration enabling reagent'' (SER) in the purification of solution-phase combinatorial libraries

被引：62

作者：

Parlow, JJ

Naing, W

South, MS

Flynn, DL

机构：

[1] Parallel Med. Combinatorial Chem. S., St. Louis, MO 63167

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 46期

关键词：

D O I：

10.1016/S0040-4039(97)10139-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A specific example of a Sequestration Enabling Reagent (SER), tetrafluorophthalic anhydride, is used in the purification of solution-phase reactions involving amines with electrophiles. The SER is added to an incomplete reaction mixture containing product, amine, and electrophile. The SER covalently reacts with remaining amine, affording a derivatized amine with an artificially-imparted acid rag. This ''tagged'' amine is now sequesterable by the same CMR/R polyamine resin used to sequester the electrophile and both are easily removed from the reaction mixture affording pure product. (C) 1997 Elsevier Science Ltd.

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页码：7959 / 7962

页数：4

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