Rapid purification of small molecule libraries by ion exchange chromatography

被引：126

作者：

Siegel, MG

Hahn, PJ

Dressman, BA

Fritz, JE

Grunwell, JR

Kaldor, SW

机构：

[1] Lilly Research Laboratories, A Division of Eli Lilly, Lilly Corporate Center, Indianapolis

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 19期

关键词：

D O I：

10.1016/S0040-4039(97)00650-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Amines and acylated amines are synthesized in traditional solution phase reactions, then rapidly purified by ion exchange chromatography to yield pure products. In some instances, impurities devoid of ionizable functionality can be covalently modified prior to purification. The generic purification sequence is applicable to a variety ol. reactions, and is amenable to automation with commercially available equipment. (C) 1997 Elsevier Science Ltd.

引用

页码：3357 / 3360

页数：4

共 13 条

[1] Novel solution phase strategy for the synthesis of chemical libraries containing small organic molecules
Cheng, S
Comer, DD
Williams, JP
Myers, PL
Boger, DL
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (11) : 2567 - 2573
[2] Dorfner K., 1972, ION EXCHANGERS PROPE
[3] Ion-exchange resins for solution phase parallel synthesis of chemical libraries
Gayo, LM
Suto, MJ
[J]. TETRAHEDRON LETTERS, 1997, 38 (04) : 513 - 516
[4] Solid-phase organic reactions: A review of the recent literature
Hermkens, PHH
Ottenheijm, HCJ
Rees, D
[J]. TETRAHEDRON, 1996, 52 (13) : 4527 - 4554
[5] Use of solid supported nucleophiles and electrophiles for the purification of non-peptide small molecule libraries
Kaldor, SW
Siegel, MG
Fritz, JE
Dressman, BA
Hahn, PJ
[J]. TETRAHEDRON LETTERS, 1996, 37 (40) : 7193 - 7196
[6] Rapid, solid phase extraction technique for the high-throughput assay of darifenacin in human plasma
Kaye, B
Herron, WJ
Macrae, PV
Robinson, S
Stopher, DA
Venn, RF
Wild, W
[J]. ANALYTICAL CHEMISTRY, 1996, 68 (09) : 1658 - 1660
[7] A new methodology for combinatorial synthesis. Preparation of diverse quinoline derivatives using a novel polymer-supported scandium catalyst
Kobayashi, S
Nagayama, S
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (37) : 8977 - 8978
[8] LAWRENCE RM, 1996, C MOL DIV COMB CHEM
[9] The use of anion exchange resins for the synthesis of combinatorial libraries containing aryl and heteroaryl ethers
Parlow, JJ
[J]. TETRAHEDRON LETTERS, 1996, 37 (30) : 5257 - 5260
[10] Fluorous synthesis: A fluorous-phase strategy for improving separation efficiency in organic synthesis
Studer, A
Hadida, S
Ferritto, R
Kim, SY
Jeger, P
Wipf, P
Curran, DP
[J]. SCIENCE, 1997, 275 (5301) : 823 - 826

← 1 2 →