Rapid purification of small molecule libraries by ion exchange chromatography

被引：126

作者：

Siegel, MG

Hahn, PJ

Dressman, BA

Fritz, JE

Grunwell, JR

Kaldor, SW

机构：

[1] Lilly Research Laboratories, A Division of Eli Lilly, Lilly Corporate Center, Indianapolis

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 19期

关键词：

D O I：

10.1016/S0040-4039(97)00650-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Amines and acylated amines are synthesized in traditional solution phase reactions, then rapidly purified by ion exchange chromatography to yield pure products. In some instances, impurities devoid of ionizable functionality can be covalently modified prior to purification. The generic purification sequence is applicable to a variety ol. reactions, and is amenable to automation with commercially available equipment. (C) 1997 Elsevier Science Ltd.

引用

页码：3357 / 3360

页数：4