Role of NKT cells in allergic asthma

被引：56

作者：

Iwamura, Chiaki ^{[1
]}

Nakayama, Toshinori ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Med, Dept Immunol, Chiba, Japan

来源：

CURRENT OPINION IN IMMUNOLOGY | 2010年 / 22卷 / 06期

关键词：

KILLER T-CELLS; INDUCED AIRWAY HYPERREACTIVITY; IFN-GAMMA PRODUCTION; INVARIANT NKT; BRONCHIAL-ASTHMA; IMMUNE-RESPONSE; INFLAMMATION; ACTIVATION; DISEASE; OZONE;

D O I：

10.1016/j.coi.2010.10.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T helper 2 (Th2) cells play crucial roles in the development of allergic asthma, while various distinct cell populations also contribute to the pathogenesis of the disease. Invariant natural killer T (iNKT) cells produce large amounts of cytokines such as IL-4 and IFN gamma upon stimulation with a ligand, a-galactosylceramide, and regulate various immune responses. Recently, a critical role of iNKT cells in the mouse model of asthma and also in asthma patients has been reported, while some contradictory results have also been described. Here, we summarize the experimental results in mouse and human systems, and discuss the current understanding of the role of NKT cells in the pathogenesis of asthma, including a possible mechanism by which iNKT cells are activated in asthma patients.

引用

页码：807 / 813

页数：7

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