Indole and (E)-2-hexenal, phytochemical potentiators of polymyxins against Pseudomonas aeruginosa and Escherichia coli

被引：15

作者：

Kubo, A ^{[1
]}

Lunde, CS ^{[1
]}

Kubo, I ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY,CNR,ESPM,DEPT ENVIRONM SCI POLICY & MANAGEMENT,BERKELEY,CA 94720

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1996年 / 40卷 / 06期

关键词：

D O I：

10.1128/AAC.40.6.1438

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Combinations of polymyxins and phytochemicals were tested for antimicrobial activity against two gramnegative bacteria. Various degrees of potentiation were found against Pseudomonas aeruginosa and Escherichia coli with (E)-2-hexenal and indole, Three-compound combinations were found to further increase the activity of polymyxin B sulfate and colistin methanesulfonate against both bacteria. Combinations with colistin against P. aeruginosa resulted in the highest degree of potentiation, with a 512-fold increase in colistin antimicrobial activity. These results indicate the potential efficacy of phytochemical combinations with antibiotics to enhance total biological activity.

引用

页码：1438 / 1441

页数：4

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