Structural analysis and haplotype diversity in swine LEP and MC4R genes

被引：20

作者：

D'Andrea, M. ^{[1
]}

Pilla, F. ^{[1
]}

Giuffra, E. ^{[2
]}

Waddington, D. ^{[3
]}

Archibald, A. L. ^{[3
]}

机构：

[1] Univ Molise, Dip SAVA, I-86100 Campobasso, Italy

[2] Parco Tecnol Padano CERSA, Lodi, Italy

[3] Roslin Inst, Div Genet & Genom, Roslin EH25 9PS, Midlothian, Scotland

来源：

JOURNAL OF ANIMAL BREEDING AND GENETICS | 2008年 / 125卷 / 02期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Casertana pig breed; haplotypes; leptin; melanocortin-4; receptor;

D O I：

10.1111/j.1439-0388.2007.00689.x

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Knowledge about structural variation of candidate genes could be important to improve breeding selection scheme and preserve genetic variability in livestock species. Leptin (LEP) and melanocortin-4 receptor (MC4R) genes are involved in the energetic pathway and are obvious candidate genes for fatness. By sequencing LEP and MC4R genes in 72 pigs belonging to lean (Large White and Duroc), fat (Meishan and Casertana) breeds and also Wild Boar, 98 polymorphic sites, of which 91 were novel, were found in the Leptin sequence while only the previously described mutation was found in the MC4R gene. A total of 18 LEP haplotypes were observed and their distribution was unequal among the breeds. The phylogenetic analysis showed two haplotype branches distinguishing between lean and fat breeds.

引用

页码：130 / 136

页数：7

共 26 条

[21] Polymorphism of the porcine leptin gene promoter and analysis of its association with gene expression and fatness traits [J].